Postdoctoral Research Associate – Geeleher Lab; dry lab

Location

Memphis, TN

Category

Postdoc

Department

Computational Biology

Shift

Weekday Day

Position Type

Full Time

Scheduled Weekly Hours

40

JR7387

The Geeleher Lab tightly integrates computational/AI-based analysis of high-throughput genomics datasets (e.g. single-cell / spatial genomics, functional screens) with wet-bench experimental work. We ultimately aim to improve outcomes for children with cancer, with a particular focus on neuroblastoma and other high-risk pediatric solid tumors. Our hybrid wet-dry lab has led publications in journals including Nature, Genome Biology, the Journal of the National Cancer Institute, and Nature Communications, and is supported by NIH funding, including R01 (NCI renewal recently scored 1st percentile) and R35 awards, as well as institutional funding from ALSAC.We

are seeking a dry-lab postdoctoral scientist to lead computational and AI/ML-driven efforts to identify therapeutic target pairs from atlas-scale pediatric single-cell and spatial transcriptomic datasets. We are particularly interested in developing AI- and agent-based approaches to nominate cell-surface antigen combinations for emerging dual-targeted and logic-gated therapeutic strategies, including AND-gated bispecific antibody-drug conjugates and logic-gated cellular therapies. Pediatric cancers are especially well suited to these approaches because many are driven by aberrant developmental or ectopic transcriptional programs that generate highly disease-selective cell states.

However, systematic efforts to identify and prioritize such target pairs at scale remain very limited, creating substantial scope for discovery. Our integrated wet-dry lab is particularly well positioned to move prioritized candidates through experimental validation and preclinical development, with the goal of unlocking new therapeutic strategies for children with cancer.

Examples of recent representative papers led by dry-lab scientists in our lab (listed as first author), with strong ML/AI components include:https://www.biorxiv.org/content/10.64898/.709438v2 (24)00368-9 also routinely publish tightly integrated wet-lab/computational studies, with recent first authorships by Geeleher Lab members, including: candidate will be strongly supported in their career objectives, regardless of whether their goals are academic or industry, and will be supported in writing grants/fellowships if they are interested in the academic faculty path.

This position is located in Memphis, TN (100% on-site position), and relocation assistance is available. Salary and benefits follow the (highly competitive) St. Jude postdoctoral compensation scale (www.stjude.org/postdoc).

Position Responsibilities:

• Lead independent computational/AI research projects focused on identifying and prioritizing candidate targets for emerging bispecific therapeutic strategies in pediatric cancers.

• Develop AI and agent-based workflows integrating large-scale single-cell, spatial transcriptomic, bulk genomic, functional-genomic, and pharmacologic datasets to nominate disease-selective vulnerabilities and target combinations.

• Nominate disease-selective cell-surface antigens and antigen combinations based on malignant-cell specificity, co-expression, spatial localization, normal-tissue expression, targetability, and therapeutic rationale.

• Work closely with wet-lab scientists to design follow-up validation studies and interpret experimental results in the context of large-scale datasets.

• Generate publication-quality analyses, figures, and visualizations, and contribute to study design, data interpretation, and project strategy.

• Lead projects toward publication, including drafting manuscripts, preparing…