Postdoctoral Fellow Gene- and Metabolism-Targeting Therapeutics

Postdoctoral positions are available in the lab of Dr. Jian Xu at Department of Pathology and Center of Excellence for Leukemia Studies (CELS) e Children's Research Hospital to study the genetic, epigenetic and metabolic processes that control stem cell development, blood disorders, and childhood cancers. We employ high-throughput epigenomics, metabolomics, single-cell multiomics, (epi) genome editing, and preclinical models to define disease-associated epigenetic and metabolic programs that control stem cell development, and how these processes go awry in cancer progression.

Our lab is equipped with cutting-edge genomics, metabolomics, molecular biology, and bioinformatics platforms, including in-house LC-MS and GS-MS-based metabolomic platforms, illumina sequencer, 10xGenomics single-cell technologies, and flow cytometry. Our team brings together enthusiastic scientists with diverse backgrounds and provides a wide range of perspectives in a multi-disciplinary and collaborative team setting. Since establishing the laboratory, our team has published a series of impactful papers including:

• Development of CRISPR CAPTURE for in situ analysis of chromatin interactions (
  Cell 170:1028)
• Loss of EZH2 reprograms BCAA metabolism to drive leukemic transformation (
  Cancer Discovery 9:1228)
• Epigenetic silencing of LINE-1 retrotransposons is an AML-selective dependency (
  Nature Genetics 53:672)
• Mechanisms driving resistance to IDH-targeting therapies in myeloid leukemia (
  Cancer Discovery 13:170)
• A glutamine metabolic switch controls normal and pathological erythropoiesis (
  Science 386:eadh
  9215)

• Identify and target metabolic and epigenetic vulnerabilities in blood cancers and therapy response
• Develop non-coding RNA-based nucleic acid therapeutics for inherited blood disoders
• Target disease-associated metabolic processes using pharmacologic and genetic approaches
• Develop AI/ML tools for integrating metabolomics, transcriptomics, and genomics datasets across development and disease

Candidates must hold a Ph.D. and/or M.D. degree with a strong background in hematology/oncology, metabolism research, biochemistry, molecular biology, and/or a related field. The ideal candidate will exhibit independence, flexibility and creativity with a record of scientific productivity. Previous experience in metabolomics, computational biology, and/or hematology-oncology is strongly preferred.

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