Director of Office of the CEO, Founder in Residence

Responsibilities

• We are seeking exceptional entrepreneurial builders to join Billion To One ’s newly launched Founder in Residence Program as a Director in the Office of the CEO. In this 12‑to‑18 month program, you will work directly with the CEO and Chief of Staff on the company’s highest‑priority strategic and operational projects, and graduate into a permanent senior operating role at the Director or Senior Director level.
• This is one of the highest‑leverage roles  will be deployed onto a portfolio of high‑impact projects each quarter ‑ from new product launches, to commercial strategy, to operational turnarounds, to incubating new business lines and capabilities. Your portfolio of 1‑2 projects will be revisited each quarter so you are always working on what matters most to the company.
• This role is a hybrid (onsite 3 days/week) position and reports directly to the VP of Business Operations and Chief of Staff, with active co‑sponsorship from the CEO.
• Own CEO‑Priority Projects:
  Lead one or more of Billion To One ’s highest‑priority strategic and operational initiatives each quarter, sourced directly from the CEO and Office of the CEO. Project types span new product launch support, commercial and go‑to‑market strategy, business development, operational excellence, competitive response, and the incubation of new business lines.
• Find Broken Things and Fix Them:
  Identify under‑performing processes, workflows, or functions. Diagnose root cause, design the fix, and drive execution end‑to‑end with cross‑functional teams.
• Cross‑Functional Leadership:
  Lead and influence cross‑functional teams across Sales, Product, Lab Operations, Compliance, Reimbursement, Finance, BD, Legal, and HR. Build deep working knowledge of how each function operates through the projects you lead.
• Operate with AI:
  Drive results in ambiguous, fast‑moving environments. Use first‑principles thinking and AI‑native fluency to move faster than the company would otherwise be able to.
• CEO and Executive Partnership:
  Participate in CEO meetings, present to the executive team on an ongoing basis, and serve as a trusted thought partner to the CEO and Chief of Staff on company‑shaping decisions.

• Suite of benefit plans.
• Paid medical, pregnancy, parental and family leaves.
• Retirement savings program with company contribution.
• Generous equity package.
• Free daily onsite lunches provided from top eateries.
• Latest and greatest hardware (laptop, lab equipment, facilities).
• Free onsite EV charging (compatible with all EVs, including Tesla).
• Working with a team of rockstars who bring out the best in everyone.
• The ability to indirectly or directly change the lives of hundreds of thousand patients.
• Open, transparent culture that includes weekly Town Hall meetings.

• First‑principles thinker, builder, AI‑native, and exceptionally sharp.
• First‑time founder or current senior executive (COO, CPO, VP‑level) at a top scale‑up, or top‑tier management consultant from MBB or a top boutique firm with healthcare or life sciences exposure, and operational experience under your belt.
• 6‑10+ years of building or operating experience, with a track record of exceptional impact in entrepreneurial or builder‑oriented environments.
• Strong written and verbal communication, including with executives and the board.
• AI‑native fluency in using AI tools to move faster and amplify individual leverage.
• On‑site position (relocation to SF Bay Area required).
• Builder mentality – bias to action, comfort with ambiguity, ability to operate without a playbook.
• First‑principles thinker with exceptional analytical horsepower.
• Genuine interest in molecular diagnostics and the Billion To One  mission.
• Track record of building 0‑to‑1: new products, new functions, new business lines, or new operating mechanisms.
• Prior exposure to healthcare, life sciences, molecular diagnostics, or other regulated industries.
• Existing network in the founder community, YC ecosystem, or top scale‑up operating community.