Scientist II​/Senior Scientist, Protein Science: Antibody​/ADC Analytics and Engineering

Overview

Scientist II / Senior Scientist, Protein Science:
Antibody / ADC Analytics and Engineering

Hexagon Bio leverages a genomics-based platform and understanding of natural product evolution to develop next-generation medicines for human disease, including Antibody Drug Conjugates (ADCs) with novel payloads. Our algorithms identify gene clusters that encode the machinery needed to produce specialized metabolites and our unique platform allows us to produce new chemical leads and novel payloads based on these findings. We use data science, genomics, synthetic biology, and automation to discover and develop potent, evolutionarily refined small molecules from fungal genomes, paving the way for groundbreaking advancements in ADC therapeutics.

As a Scientist in the Protein Science group, you will be part of a highly collaborative, interdisciplinary team, and will be responsible for the development and characterization of ADCs, contributing to the advancement of groundbreaking therapeutic interventions. The candidate should have a strong foundation in antibodies from discovery through early development and be highly knowledgeable in antibody analytical methods and antibody production and engineering to enable the advancement of innovative ADCs.

By supporting collaborative efforts between cell biology, chemistry, and protein science teams the candidate will support the development of first-in-class ADC therapies. Candidates should demonstrate independence, scientific curiosity, efficient time management, excellent organizational and communication skills, and a passion for science. The role is expected to be primarily focused on laboratory work with potential for CRO management.

• Drive analytical efforts supporting the development of novel therapeutic ADCs.
• Drive antibody production and protein engineering efforts.
• Perform antibody and ADC characterization and develop ability assessments using a variety of biophysical and biochemical analytical methods.
• Drive in vivo study workflows with in-use stability testing and dose formulation analyses
• Work closely with biologists and medicinal chemists to advance antibody drug conjugates from discovery through to development.
• Analyze and interpret data, and effectively communicate findings to multi-disciplinary teams.

• PhD in Biochemistry, Bioengineering, Biophysics, Structural Biology, or related disciplines with at least 3-5 years of experience in the biotech and/or pharma industry.
• Extensive hands-on experience with therapeutic antibody characterization and early development
• Demonstrated expertise with analytical approaches for antibody characterization including HPLC-SEC / HIC / RP, large molecule intact mass spec, capillary electrophoresis, nano
  
  DSF and binding (BLI/SPR/ELISA). Similar analytical experience with ADCs is desirable.
• Experience working with Contract Development Manufacturing Organizations (CDMOs) including assay qualification / validation and report generation is preferred
• Hands-on laboratory experience in antibody production workflows including expression and purification (i.e. AKTA: Affinity / IEX / HIC / SEC), and QC.
• Experience with antibody engineering workflows including optimization of molecule properties
• Ability to tackle complex scientific problems in a cross-functional environment.
• Effective communication and ability to coordinate tasks across multiple projects as part of a multidisciplinary research team.
• Proven ability to support and enable team members.
• Initiative and boldness to dive into a fast-paced new startup.

• A flexible and dynamic work environment where you pave your own path, Hexagon cultivates employees  unique strengths at all levels and provides mobility across departments.
• “All Hands Meetings” provide an opportunity to share company and team updates. These meetings are rooted in our value of transparency. They are designed to foster a culture of collaboration, curiosity, and open communication.
• Competitive compensation and a robust benefits package: a comprehensive suite of medical, dental, and vision insurance plans through Tri Net, which offers additional voluntary benefits (pet insurance,…