Senior Associate Scientist - Flow Cytometry

Location: Mattawan

For 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform.

In return, we’ll help you build a career that you can feel passionate about.

Job Overview The Immunotox group supports drug development by investigating immune responses using flow cytometry. The group supports immunophenotyping endpoints, isolation of PBMCs and cell-based stimulation assays. Utilizing these platforms/assays, the team is responsible for the method development, validation and routine sample analysis in both the regulated and non-regulated space of non-clinical studies. Essential Functions Effectively manage a portfolio of sample analysis projects while ensuring timelines are met in a single operational area with oversight

Execute review and approval of data with oversight for final scientific/technical decisions within a single operational area Develop understanding of compliance expectations to respond to quality assurance audit observations in appropriate software with oversight

Assist with oversight the completion of laboratory investigations, assay troubleshooting and quality observations

Assist in problem solving for technical and/or regulatory issues with oversight

Responsible for writing and preparing study plans/protocols/amendments with minimal oversight

Participate in Sponsor visits/tours with minimal oversight

Develop expertise in developing and validating quantitative/qualitative methods/procedures with limited complexity/scope in one operational area with minimal oversight

Perform data analysis using appropriate software with minimal oversight

Develop critical thinking, troubleshooting and time management skills aligned with needs of operational areas

Demonstrate effective communication skills through informal discussions with peers, supervisor, and team;
Function as a liaison, maintaining timely and frequent communication between CRL and Sponsor/Client/SD with minimal oversight

Ensure scientific integrity of studies with minimal oversight

Function as a Principal Investigator, Individual Scientist and/or Study Director as assigned with minimal oversight

Actively communicate and collaborate across operational areas in order to adhere to timelines and produce quality data Efficiently perform and document all procedures, materials and results in compliance with applicable regulatory standards as applicable (protocols, methods, SOPs, etc.)Write, review and approve deviations with oversight

Develop knowledge of regulatory and GXP requirements, industry standards and company SOPs within one operational area Effectively manage a small portfolio of research projects including method development and validation while ensuring timelines are met in a single operational area with oversight

Performs all other related duties as assigned

Job Requirements Qualifications Bachelor ’s degree (BA/BS) with 5-7 years of relevant working experience. Master’s degree (MS) with 1-2 years of relevant work experience. Doctorate degree (PhD) with no experience

Ability to communicate verbally and in writing at all levels inside and outside the organization

Basic familiarity with Microsoft Office Suite Computer skills, commensurate with Essential Functions, including the ability to learn a validated system

Ability to work extended hours beyond normal work schedule to include, but not limited to evenings, weekends, extended shifts, and/or extra shifts

Sometimes on short notice

Ability to work under…