Principal System Administrator

Histo Sonics is a commercial-stage medtech company advancing the Edison® System, a novel non-invasive sonic beam therapy based on histotripsy. Since receiving FDA De Novo grant for the non-invasive destruction of liver tumors in 2023, the company has progressed beyond initial market entry into commercial expansion, reimbursement momentum, and ongoing clinical and pipeline development. In addition to its current liver tumor indication, Histo Sonics is pursuing future indications across multiple applications including kidney, pancreas, prostate, neuro, women’s health, and other significant underserved human health areas, to realize the broader potential histotripsy across multiple disease states and medical specialties.

We offer an exciting work culture where cutting-edge science meets real-world application, and each team member’s contribution is important to our success in ensuring our physicians and their patients get what they need most.

Plymouth, MN

The Principal System Administrator is the senior-most individual contributor within the Histo Sonics System Administration function and is a member of a larger, multi-site IT team that supports Histo Sonics as a whole. This is a hybrid position based out of the Plymouth, MN office. The role owns the design, operation, and reliability of the organization’s cloud and on-premises infrastructure, enterprise identity and authentication services, backup and disaster recovery, and environments that support deployed systems in the field.

The Principal System Administrator establishes the organization’s observability practice and provides the primary technical execution behind the Information Systems relationship with the AI and R&D Infrastructure team within the CTO organization, a partnership owned by the Senior Director, Information Systems and Security. The role serves as the highest level of technical escalation for Information Systems infrastructure and sets technical direction and standards for the System Administration function.

• Design, deploy, administer, and maintain the organization’s corporate and product production environments, including compute, storage, networking, identity and access management, and cost governance, along with on-premises server, virtualization, and storage infrastructure.
• Serve as the primary administrator for the product production environment, including environment design, capacity planning, configuration standards, and ongoing global operational support.
• Lead the transition of internal systems to be centrally managed by Information Systems, and plan, design, and execute infrastructure buildouts for new and expanded facilities in coordination with Facilities, Networking, and Security stakeholders.

• Design, implement, and administer the organization’s monitoring and observability platform, covering metrics, logs, traces, synthetic checks, predictive trending, and alerting across cloud and on-premises infrastructure.
• Define service level objectives, alert thresholds, and escalation paths for mission-critical and customer-facing systems, and maintain dashboards and reporting on system health, capacity, and performance.
• Serve as a senior technical responder for major infrastructure incidents, conduct root cause analysis, drive corrective and preventive actions to completion, and participate in an on-call rotation for critical after-hours support.

• Define and maintain infrastructure-as-code for cloud and on-premises resources, along with the CI/CD pipelines and configuration management tooling used to deploy and maintain them, ensuring environments are reproducible, version-controlled, and peer-reviewed.
• Design, implement, and maintain enterprise-level cloud governance under the direction of the Senior Director, Information Systems and Security, including cloud resource hierarchy, subscription and account management, management group structure, and tenant-level policy.
• Author and maintain organizational cloud standards for naming, tagging, cost…