Clinical Research Manager II

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Minneapolis, MN, US

2 days ago Requisition

Where Purpose Meets Progress

At the Minneapolis Heart Institute Foundation (MHIF), your work supports patient-centered care and helps advance cardiovascular research and education. As a Clinical Research Manager II (CRM II), you will do more than oversee research operations—you will provide strategic leadership, build high-performing teams, and strengthen the partnerships and programs that help change and save lives.

Summary

At Minneapolis Heart Institute Foundation, we believe our people are our greatest asset and our culture is what sets us apart. Every role contributes to advancing cardiovascular care through research, education, and trusted partnerships, and every employee plays an important role in improving lives around the world. We are committed to fostering a collaborative, innovative, and mission-driven workplace where people feel valued, supported, and empowered to grow.

The Clinical Research Manager II (CRM II) provides advanced managerial and strategic leadership for large, complex clinical research and education portfolios across multiple domains. This role partners closely with Principal Investigators, research teams, executive leadership, physicians, and industry collaborators to shape portfolio strategy, optimize resources, and advance organizational priorities.

The CRM II leads enterprise-wide initiatives, drives cross-functional collaboration and integration, mentors research staff and other Clinical Research Managers, and may oversee shared services or multiple enterprise-level functions. This role balances day-to-day operational oversight with long-term planning, financial stewardship, innovation, and external relationship management.

Primary Responsibilities

Portfolio Strategy & Operations

• Oversee large, complex clinical research and education portfolios across multiple domains.
• Partner with Principal Investigators and organizational leaders to influence portfolio strategy, long-term planning, and innovation.
• Ensure research programs align with MHIF’s long-term vision, organizational goals, and standards of quality and compliance.
• Lead strategic planning, resource utilization, and resource allocation for complex portfolios.
• Monitor operational performance, address advanced issues, and implement solutions that strengthen efficiency, engagement, and outcomes.
• Support the financial health of assigned portfolios through sound business judgment, planning, and oversight.
• Maintain awareness of applicable clinical research regulatory requirements and compliance standards.
• Lead one or more enterprise-wide projects and initiatives with broad organizational impact.
• Drive cross-functional collaboration, strategic integration, and alignment across research programs and operational functions.
• Oversee shared services teams or other functional groups in support of organizational initiatives, as assigned.
• May expand to oversee multiple enterprise-level functions and lead integration across programs.
• Sponsor and influence projects that advance innovation, optimization, and collaboration across research specialties.
• Collaborate with executive leadership to identify opportunities, address organizational priorities, and support sustainable growth.
• Provide direct supervision and leadership for research staff and may lead cross-functional teams as portfolio needs expand.
• Build engaged, high-performing teams through clear expectations, accountability, coaching, and performance management.
• Mentor research staff and other Clinical Research Managers, fostering professional development,…