Sr. Director, Commercial Supply Chain

Job Description

Rezolute is a late-stage rare disease biopharmaceutical company focused on developing transformative therapies for patients living with severe metabolic and endocrine disorders. Our mission is to bring hope and meaningful solutions to patients and families affected by rare and difficult-to-treat diseases through scientific innovation, collaboration, and integrity.

Rezolute’s lead investigational therapy, RZ358 (ersodetug), is a fully human monoclonal antibody in late-stage clinical development for the treatment of hypoglycemia due to congenital and acquired forms of hyperinsulinism (HI). As Rezolute expands its medical and scientific focus into tumor-related hyperinsulinism (tumor HI), most commonly related to pancreatic neuroendocrine tumors (insulinomas) or paraneoplastic hypoglycemia (NICTH), the company is committed to advancing novel therapeutic strategies that address this rare and complex form of hypoglycemia associated with insulin-secreting tumors and related neuro-oncology disorders

The Sr.
Director, Commercial Supply Chain will lead supply chain strategy and operations as Rezolute transitions from late-stage clinical development to commercial launch. This individual will establish scalable, compliant, and efficient supply capabilities to ensure uninterrupted supply of investigational and commercial products across global markets. The role requires a strategic, hands-on leader who can design the future-state operating model, build critical systems and partnerships, and lead a growing team through commercialization while supporting ongoing clinical supply operations.

• Develop and execute the supply chain strategy supporting launch and commercial operations both domestically and abroad.
• Define stage-appropriate operating models, governance, and organizational structure required to support commercial supply.
• Partner with External Manufacturing, Quality, Regulatory, and Finance to ensure seamless integration of supply, inventory, logistics, and planning activities.
• Serve as Supply Chain lead for commercialization readiness and launch planning initiatives.

• Serve as the senior functional leader and subject matter expert for Supply Chain Operations, including strategic and operational leadership. Support, guide, and integrate systems and capabilities that provide uninterrupted supply for ongoing and new clinical studies.
• Collaborate closely with the clinical supply leader to ensure comprehensive supply planning, risk management, and compliance with global GxP standards.
• Ensure alignment between clinical and commercial supply strategies to facilitate smooth transition through development and launch.
• Support clinical supply performance reviews, resource planning, and vendor management.

• Development a robust integrated supply and inventory planning system to ensure manufacturing readiness, continuity, and optimized global inventory levels.
• Establish and oversee Sales & Operations Planning (S&OP) processes to align supply, demand, and financial plans.
• Establish and maintain GMP and SOX-compliant inventory systems supporting both manufacturing and distribution needs.
• Lead scenario and risk-based planning to guide production and supply decisions.
• Optimize safety stock levels and manage excess and obsolete inventory to minimize working capital impact.
• Drive launch readiness through coordinated supply chain planning and execution.

• Establish central Global Trade Compliance (GTC) framework including unified GTC policy, SOPs/WIs, and recordkeeping system(s) to support retention and audit requirements.
• Ensure compliant and efficient cross-border movement of materials through oversight of import/export operations, customs documentation, and duty optimization strategies.
• Collaborate across departments (e.g., External Manufacturing, Tech Ops) to coordinate decentralized logistics execution.
• Oversee Harmonized Tariff Schedule (HTS) classification and trade compliance audits and conduct periodic stakeholder training.
• Provide input and support for Shipping System Qualification (SSQ) activities to ensure the compliant and efficient movement of materials within the global logistics network

• Partner with Market Access to translate channel strategies into coordinated com