Senior Scientist - Bioanalytical Method Development; LC-MS​/MS

Senior Scientist - Bioanalytical Method Development LC-MS/MS

Senior Method Development Scientist will develop bioanalytical methods utilizing contemporary mass spectrometry techniques (LC-MS/MS & HRMS) and in collaboration with Inotiv's Bioanalytical Group within the Drug Metabolism & Pharmacokinetics Department. The range of method development activities will include but not be limited to traditional small molecules, antibodies, fusion proteins, ADCs, oligonucleotides, and peptide therapeutics, spanning early discovery staged activities through drug candidate selection.

As part of the DMPK Department the senior method development scientist will support the broader Discovery and Translational Sciences Division, serving as a subject matter expert in scoping new bioanalytical proposals for clients, evaluating feasibility of LC-MS/MS method development, troubleshooting challenging methods across a wide variety of species and matrices, and partnering with pharmacology and toxicology teams to execute in vitro, in vivo, and ex vivo investigations.

Join Inotiv in embracing research and science to impact the health and well-being of people all over the world.

• Develop highly sensitive LC-MS/MS and HRMS methods for large (oligonucleotides, proteins, antibodies, ADCs, biomarkers, etc) and small molecules in biological matrices.
• Utilize and interpret scientific theories, concepts, techniques in bioanalytical and mass spectrometry studies and accept leadership role in developing novel scientific approaches.
• Coordinate, facilitate, and implement intercompany method transfers and implementation of incoming transfers from clients.
• Communicate project timelines, status, and data to Principal Investigators, Project Management, and clients effectively addressing any issues that may arise.
• Ability to coordinate and execute on multiple projects simultaneously and respond to unscheduled deadlines and client needs.
• Demonstrate an understanding of Best Practices, SOPs and Good Laboratory Practice Regulations (21
  
  CFR, Part 58) as these relate to study-specific services provided, this job description, and general facility operations.
• Training and mentoring junior scientists within and across departments.
• Collaborate with leadership on long-range planning and strategy for departmental growth.
• Perform other duties as assigned.

• Experience, skills, and abilities must include knowledge of contemporary bioanalytical techniques, including wet chemistry separations, liquid chromatography, and mass spectrometric analysis (LC-MS/MS, HRMS), instrument operation, maintenance, and data processing.
• Proven track record of method development for large and small molecules.
• Ability to incorporate software in the maintenance of databases to collate and catalog records and inventory.
• Working knowledge of laboratory software, system software, and Microsoft applications.
• Independence in the laboratory and data work-up phases of research.
• A working knowledge and awareness of general laboratory procedures.
• Good written and oral communication skills.
• Ability to adhere to all safety regulations and procedures.

• PhD in Organic Chemistry, Biochemistry, Analytical Chemistry or related discipline with 2+ years of industrial bioanalytical experience following Post Doctoral training.
• M.Sc. in a discipline previously described with 5+ years direct industrial bioanalytical experience.
• Candidates possessing working knowledge of in vitro metabolism/biotransformation, Pharmacokinetic modeling, analysis, interpretation and simulation desirable.

• Work is normally performed in a typical interior office work or laboratory environment.
• Work environment involves exposure to potentially dangerous materials and situations that require following extensive safety precautions and may include use of protective equipment.
• The noise level is usually moderate.
• This position will frequently be involved with radiant/electrical energy, solvents, grease, oil, irritants, acids, bases, and other hazardous chemicals, electro‑mechanical hazards, flammable materials and…