Principal Scientist, Medicinal Chemistry; ADC and Bioconjugation

Responsibilities

• Identify new ADC opportunities from internal pipeline/external landscape; develop project proposals cross-functionally; present at scientific review meetings; lead projects through nomination of clinical candidate and early preclinical development.
• Set ADC program strategy for long-term growth; assess new projects/modalities; guide existing ADC teams.
• Maintain awareness of latest technologies/platforms/assets; support diligence and make recommendations.
• Coordinate medicinal chemistry for ADC payload design/optimization and devise linker strategies.
• Expand bioconjugation capabilities; design, synthesize, and purify protein bioconjugates across medicinal chemistry, protein therapeutics, and discovery biology.
• Enable structured data acquisition for ADC modalities with Data Sciences/Informatics.
• Train/technically support team members on bioconjugation techniques and ADCs.
• Collaborate across R&D and with external partners; present scientific results.

• PhD (+5 yrs), MS (+8 yrs), or BS (+10 yrs) in organic chemistry or equivalent with ADC/medicinal chemistry/bioconjugation focus.
• Proven bench success and leadership in ADC drug discovery.
• ADC characterization experience (SEC, HIC, RPLC, high-resolution MS for DAR); IP collaboration.
• Experience designing linker cleavage mechanisms and hydrophilic mask strategies.
• Familiarity with automation for high-throughput conjugation; enzymatic conjugation methods.
• Track record as project team leader; strong written/verbal communication; collaboration; scientific rigor.

• Advanced degree years in organic chemistry (PhD +8, MS +10, BS +12) with ADC/medicinal chemistry/bioconjugation focus.

Salary range: $–$; may include discretionary bonus, stock-based long-term incentives, paid time off, and medical/dental/vision/life insurance.