Sr Director, Protein Therapeutics

Responsibilities

• Lead the in silico antibody discovery team to identify novel binding proteins with optimal drug‑like characteristics.
• Collaborate with in vivo and in vitro antibody discovery teams to analyze B cell repertoires (immunized animals) and library outputs using paired and unpaired NGS.
• Partner with Research Data Sciences to build sequence analytics pipelines, identify antibody hits for hit‑to‑lead screening/evaluation, and develop AI/ML models to streamline lead identification via synthetic approaches.
• Use protein structural insights to expand antibody lead sequences for enhanced affinity, reduced liabilities, and improved develop ability.
• Set team vision and strategic direction; advance technology platforms and operational excellence.
• Build organizational capabilities to increase frequency and impact of antibody discovery campaigns.
• Communicate transparently with stakeholders in a highly matrixed organization.
• Demonstrate scientific rigor, attention to detail, and commitment to quality, speed, and scalability.
• Manage a diverse team; establish best practices integrating NGS and informatics pipelines into routine workflows.
• May serve as project team leader or core team member driving discovery/engineering of large‑molecule candidates.

• Basic: 10+ years with Ph.D. in molecular/cell biology, structural biology, or equivalent.
• Preferred: 14+ years with Ph.D., postdoctoral training, and significant industry experience.
• Strong experience in antigen design, immunization, and NGS for antibody discovery aligned to mechanisms of action and target product profiles.
• Strong preference: structural biology, immunology, or B cell biology.
• Expertise in antibody discovery/engineering and large‑scale sequence analysis software.
• Peer‑reviewed publications and issued patents.
• Knowledge of biologics expression/purification, functional screening assays, and develop ability assessments.
• Desirable: IND technical reports and investigator’s brochures (IB).

$–$; may include discretionary annual bonus, discretionary stock‑based long‑term incentives, paid time off, and company‑sponsored medical/dental/vision/life insurance.