Research Associate, Biotech Research, Research Scientist

ABOUT SINGULAR GENOMICS

Singular Genomics is inventing at the forefront of genomics, one of the world’s fastest-growing industries. The commercially available G4 Sequencing Platform is a powerful, highly versatile benchtop genomic sequencer designed to produce fast and accurate results. In addition, the company is currently developing the G4X Spatial Sequencer, an upgrade to the G4, which will leverage Singular’s proprietary sequencing technology, applying it as an in situ readout for transcriptomics, proteomics and fluorescent H&E in tissue, with spatial context.

Singular Genomics’ mission is to empower researchers and clinicians to advance science and medicine.

We foster a culture of creativity and technical excellence, both catalysts for innovation. We celebrate diversity, emphasize collaboration and, as we rapidly mature, we are constantly looking at ways we can do better for our people.

Our Headquarters are located on the Torrey Pines Mesa, in La Jolla, California at the center of the biotech hub. Our Manufacturing facility is in Sorrento Valley.

The Research Associate 2 will independently execute and optimize molecular biology and in‑situ multiomics workflows in support of assay development and product launch. This role combines hands‑on molecular biology, tissue‑based assays, imaging, sequencing workflows, and data analysis. The ideal candidate brings strong technical proficiency, a growth mindset, and the ability to troubleshoot and refine protocols in a collaborative and fast‑paced R&D environment.

• Independently execute and optimize molecular biology and spatial multiomics workflows with high reproducibility and attention to detail
• Perform standard molecular biology techniques including DNA/RNA purification and quantification, PCR/qPCR, gel electrophoresis, and other basic assays
• Conduct and troubleshoot tissue‑based assays including H&E staining, immunostaining, and in situ hybridization (ISH)
• Evaluate tissue morphology and assay performance to inform technical decision‑making
• Operate and maintain laboratory instrumentation, including the G4X benchtop sequencer
• Utilize imaging software (e.g., FIJI/ImageJ) to evaluate raw images
• Interpret experimental data to inform decisions and guide next steps
• Identify technical challenges and propose data‑driven solutions to improve assay robustness and workflow efficiency
• Document experimental design, protocols, and results clearly and comprehensively
• Present technical findings to cross‑functional teams and contribute to project discussions
• Collaborate with interdisciplinary teams (molecular biology, imaging, bioinformatics, engineering) to advance platform development
• Maintain laboratory inventory, ensure proper instrument maintenance, and uphold a safe and organized work environment

• Experience in executing and optimizing molecular biology and spatial multiomics workflows with high reproducibility and attention to detail
• Proficiency in DNA/RNA purification and quantification, PCR/qPCR, gel electrophoresis, and other basic molecular biology assays
• Strong background in tissue‑based assays including H&E staining, immunostaining, and in situ hybridization (ISH)
• Ability to evaluate tissue morphology and assay performance to inform technical decisions
• Experience operating and maintaining laboratory instrumentation, including benchtop sequencers
• Familiarity with imaging software such as FIJI/ImageJ for image analysis
• Strong analytical skills to interpret experimental data and guide subsequent steps
• Problem‑solving mindset to identify technical challenges and propose data‑driven solutions
  
  Excellent documentation skills to record experimental design, protocols, and results
• Excellent communication skills to present findings to cross‑functional teams
• Team‑player ability to collaborate with interdisciplinary teams
• Strong commitment to laboratory safety and organization

• Experience with spatial transcriptomics, spatial proteomics, or high‑plex imaging platforms
• Hands‑on experience with tissue handling and staining techniques (H&E, immunostaining, and/or ISH)
• Background in histology with understanding of…