Clinical Development Scientist​/Senior Clinical Development Scientist

Clinical Scientist/Senior Clinical Scientist

Tenvie Therapeutic sis developing precision‑engineered small molecule therapies to address core drivers of neurological and peripheral diseases: neuroinflammation and cellular dysfunction. Leveraging its proprietary product engine,Tenviehas the unique ability to advance both fully CNS‑penetrant and peripherally restricted products across a broad portfolio.

Tenvie’smost advanced programs, TNV
262 and TNV
108,are in Phase 1 clinical development.

TNV
262isa fully CNS-penetrant NLRP3 inhibitor targeting cardiometabolicand neuroinflammatoryindications, including obesityandcardiovascular disease,and multiple sclerosis.

TNV
108isa peripherally restricted SARM1 allosteric inhibitor targeting peripheral neuropathies.

Tenvie’sclinical pipeline is complemented by discovery-stage programs across a range of related indications.

Tenvie Therapeutics is seeking a scientifically rigorous and highly collaborative

Clinical Scientist to support the design and execution of early clinical development programs across multiple indications includingcardiometabolic and neuroinflammatory diseases. This role is ideal for candidates who have deep hands‑on study execution experience coupled with critical scientific and strategic thinking. The Clinical Scientist will work closely with Clinical Operations, Clinical Pharmacology, Biometrics, Translational Science, and Regulatory to ensure high‑quality clinical plans, protocols, and data readouts.

This role can be remote, hybrid, or on‑site, and reports within the Clinical Development group.

• Lead development of core clinical documents
  • Author or co‑author clinical sections of protocols, protocol amendments, IB updates, ICFs, clinical and scientific training material, medical monitoring plans, safety/review/ dose escalation committee charters.
  • Translate protocol intent into operational deliverables such as CRFs and eCRF completion guidelines, lab and pharmacy manuals. Develop or contribute to study‑level documents, including medical monitoring plans, safety review / dose escalation committee charters, data review plans, and statistical analysis plans
  • Draft and review clinical sections of regulatory documents and responses, including Health Authority interactions, briefing books, IND and annual reports, and safety updates
• Drive study conduct and data quality
  • Serve as Clinical Scientist lead on cross‑functional study teams for selected trials
  • Provide clinical and scientific input into site selection, eligibility reviews, and key study tools (e.g., manuals, training decks, CRFs)
  • Perform routine reviewsof patient profiles, listings, coded terms, and narratives. Monitor for trends across safety, efficacy, and protocol compliance; help define and track key data review listings and visualizations
  • Contribute to the interpretation of emerging clinical safety and efficacy data.
  • Support development and execution of safety review / dose escalation committees and data monitoring activities
• Lead data interpretation and communication
  • Lead or co‑lead integrated analyses of clinical safety/efficacy, PK/PD, and biomarker data to generate clear conclusions and next‑step recommendations
  • Prepare data summaries and presentations for internal governance, external collaborators, and advisory boards
  • Lead clinical study report authoring
  • Contribute to abstracts, posters, and manuscripts for scientific meetings and peer‑reviewed journals
• Interface with investigators and external partners
  • Provide scientific support to investigators and study sites (e.g., training, protocol clarification, scientific Q&A)
  • Participate in KOL and expert advisory boards, contributing to agenda, content, and follow‑up
  • Collaborate with CROs, central labs, imaging/biomarker vendors, and…