Senior Scientist II, Computational Chemistry

Role:
Senior Scientist II in Computational Chemistry leading drug discovery programs within a biopharma focused on RAS-addicted cancers.

design and execute computational strategies for hit identification and lead optimization, integrate SAR, structural biology, and ADME/PK data to inform compound prioritization, develop virtual screening workflows, evaluate advanced computational methods including physics-based modeling and AI/ML, and collaborate across multidisciplinary teams to accelerate therapeutic development.

• Ph.D. in computational chemistry or related field;
• 5+ years industry experience with impactful contributions to drug discovery, including publications and patents;
• expertise in protein-ligand analysis, molecular modeling, MD simulations, QM calculations, and relevant software;
• proficiency in programming languages such as Python, Bash, or R;
• excellent communication skills.

• experience with challenging modalities like macrocycles, molecular glues, covalent ligands, HPC/cloud environments, and a strong publication record.

• Oncology focus, RAS pathway, small molecules, early to late-stage (preclinical to clinical), computational drug design, interdisciplinary collaboration.

Work Setup:
Not specified.