Research Associate II: RNA​/DNA Cancer Epigenetics

Join the forefront of groundbreaking research at
City of Hope
where we're changinglives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission:
Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting‑edge research.

Dr. Jianjun Chen and Dr. Xiaolan Deng’s joint lab in the Systems Biology Department in the Beckman Research Institute at the City of Hope is in search of a Research Associate II to join their team. The lab is interested in RNA/DNA cancer epigenetics studies (focusing on both basic and translational research). The joint lab has published a series of breakthrough discoveries in top‑tier journals such as Nature
, Cell
, Cancer Cell
, Cancer Discovery
, Cell Stem Cell
, Nature Biotechnology
, Nature Genetics
, Nature Cell Biology
, and Molecular Cell
, etc. The ultimate goal of the laboratory is to translate the laboratory discoveries into the development and application of effective novel therapeutic strategies to treat cancers in the clinic. The successful candidate will assist laboratory research by providing technical assistance, preparing and arranging reagents, managing mouse colonies, ordering and inventory of stocks.

• Perform general lab maintenance and ordering, restocking lab reagents and maintaining supply stocks.
• Handle mice, including husbandry, injections (including drug treatments), and proficient collection of submandibular blood samples.
• Perform bulk plasmid purification, PCR, gel electrophoresis, genotyping, and Western blotting.
• Maintain adherent and suspension cell cultures.
• Evaluate new reagents and products for potential lab use.
• Techniques may include, but are not limited to, basic molecular biology, RNA biology, biochemistry, aseptic techniques, immunofluorescence, immunohistochemistry, and microscopy.

Your qualifications should include:

• Bachelor’s degree. Master’s degree preferred.
• Two years related research/laboratory experience with a Bachelor’s degree or one year related research/laboratory experience with a Master’s degree.
• Meticulous record keeping, impeccable organization and proficiency with databases.
• Exceptional managerial and organizational skills.
• Excellent written and verbal communication.
• Strong work ethic, highly motivated, and work well independently and in a team.

• Experience with genetic mouse models, RNA biology, tissue culture, cellular and molecular biology techniques is a big plus.
• Applicants with prior clearance for animal irradiation and/or previous experience in flow cytometry for quantifying xenograft engraftment will receive additional consideration.

City of Hope is an equal opportunity employer.