Technician, Purification

Position Summary

We are seeking a detail-oriented Technician to join our Analytical and Purification group. In this role you will support synthetic chemistry programs by identifying, purifying, and characterizing small-molecule compounds using chromatographic and mass spectrometry techniques. You will help operate an open-access / walk-up purification service, deliver high-purity compounds and analytical data back to requestors, and maintain the instrumentation and workflows that keep the discovery pipeline moving.

Technical operations (80%) – Part of analytical and purification chemistry efforts involving instrument operation and maintenance, sample handling and tracking, and delivering on upstream requestor demands on fast and flexible timelines.

Continuous Improvement/Ad-Hoc Projects (20%) – R&D efforts to improve internal capabilities as opportunities and business needs dictates and arises.

• Develop and optimize analytical and preparative methods to assess and purify compounds on LC/SFC-MS platforms for the separation, identification, and isolation of compounds submitted by client chemists using reversed-phase and normal-phase prep-HPLC, mass-directed prep-HPLC, and flash chromatography.
• Run high-throughput analysis and characterization of crude reaction mixtures and purified compounds, confirming identity and purity by UPLC/HPLC-UV, LC-MS, and (as needed) NMR.
• Support a walk-up / open-access LC-MS and purification service, assessing incoming samples and returning purified material and data with quick turnaround.
• Accurately track sample identity, recovery, and yield through analytical and purification workflows.
• Perform routine preventive maintenance, calibration, and troubleshooting of analytical and preparative instrumentation and associated software, escalating and coordinating service with vendors as needed.
• Maintain accurate, current, and well-organized records of all work either on paper or digitally in accordance with laboratory data integrity and safety standards.
• Follow all safe laboratory practices and contribute to a clean, well-run shared instrument environment including following all SOP, safety procedures and training, and proper waste management and disposal.

Assuming the completion of laboratory technical operations as listed above as priority above all other tasks, additional opportunities may include:

• Directly assist in, or provide constructive feedback to improve workflow efficiency, throughput, and chemistry performance, and help implement best practices.
• Engage in cross-team projects and deliverables.

Part of Terray’s success is nurtured by a hands-on work environment where everyone is accountable, vested in a vision of excellence, and actively taking part in the success of the business. Terray supports a positive work environment where employees can feel engaged, recognized, and empowered to be creative.

• B.S. in Chemistry, Analytical Chemistry, Organic Chemistry, Biochemistry, or a related discipline.
• Hands-on experience with analytical and preparative scale chromatography — HPLC/UPLC and prep-HPLC
• Working knowledge of chromatographic principles such as reverse and normal phase chromatography, mobile/stationary phase selection, and related chemical knowledge
• Very strong attention to detail, sample tracking discipline, and data integrity habits.
• Ability to manage a high sample throughput and competing priorities in a high-throughput, deadline-driven environment.
• Strong written and verbal communication skills; works effectively both independently and as part of a collaborative, cross-functional team.

• B.S. with 1–3+ years of relevant industry experience preferred for this level, or…