Sr. Systems and Security Administrator

Sr. Systems and Security Administrator

Metabolon is seeking a Senior Systems Administrator to be responsible for enterprise infrastructure operations across servers, virtualization, networking, Microsoft 365, and AWS cloud services. This role supports both on‑prem and hybrid environments, drives vulnerability remediation and system hardening, improves monitoring and patching processes, and automates routine tasks using scripting and configuration management tools. The position will also provide technical leadership, documentation, and escalation support across the IT team.

This role will work a hybrid schedule (Tues - Thurs in office) from our RTP, NC location.

• Design, deploy, and maintain Windows and Linux servers in on-prem or cloud environments.
• Install and maintain routers, switches, firewalls, APs, PDUs, UPSs, cameras, etc.
• Manage virtualization platforms (VMware, Proxmox, etc.) and core infrastructure services (Active Directory, DNS, DHCP, VPN, etc.).
• Administer Microsoft 365 services (Teams, Exchange, One Drive, Sharepoint, etc.).
• Maintain backup systems and perform periodic restores.
• Create and maintain documentation.
• Perform vulnerability remediation across servers and infrastructure (OS, 3rd party, firmware).
• Set up and maintain SSO for SaaS-based subscriptions.
• Partner with ISO on vulnerability scanning results and remediation timelines.
• Harden systems according to security baselines (CIS, NIST, DISA STIGs, internal standards).
• Manage privileged access, service accounts, and secrets.
• Support security incident response processes (log review, containment, and recovery).
• Ensure systems meet compliance requirements (HIPAA, ISO 27001).
• Maintain and improve server and network patching, monitoring, and alerting.
• Automate tasks using scripting and configuration management (Power Shell, Bash, Batch, Python, Ansible, Terraform, etc.).
• Administer AWS cloud infrastructure including compute, storage, IAM, and networking.
• Support hybrid identity and connectivity models.
• Apply security best practices in cloud environments (least privilege, logging, encryption).
• Serve as a technical escalation point and mentor for junior staff.

• 10+ years of hands‑on systems administration experience.
• Bachelor’s degree in Information Technology, Computer Science, or related discipline, or equivalent experience supported by applicable certifications in IT security and/or systems administration.
• Strong expertise in VMware, Windows Server, and Linux in production environments.
• Experience with installing and maintaining physical servers, storage arrays, switches, routers, firewalls, and wireless infrastructure.
• Solid understanding of networking fundamentals (TCP/IP, firewalls, load balancing, etc.) and storage protocols (iSCSI, FC, FCoE).
• Proven experience with vulnerability remediation and system hardening.
• Strong scripting and automation experience.
• Experience with backup, disaster recovery, and business continuity planning.
• Experience maintaining Microsoft 365 services.
• Experience administering AWS, Azure, or GCE cloud infrastructure.
• Experience in regulated/laboratory or security‑sensitive environments is preferred.
• Experience with Merak and Cisco firewalls, Fortinet and Cisco switches and Pure storage arrays is preferred.
• Prior experience in Desktop support is preferred.
• Must be able to work onsite at our RTP, NC headquarters.

Metabolon, Inc., is the global leader in revealing biological insights on disease state and physiological reactions in the present time through metabolomics. Leveraging one of the world’s most diverse and rich patient data sets, Metabolon is equipped to deliver biologically relevant evidence to address some of the most difficult and pressing questions in the life sciences. Every day, our work is helping to accelerate research and product development success in the biopharma, population health, consumer products, agriculture, wellness, and academic research sectors.

Metabolon was founded in 2000 and is headquartered in Research Triangle Park, North Carolina. For more information, please visit

Metabolon is an Equal Opportunity Employer and does not discriminate against any employee or applicant for employment because of race, color, religion, gender, sexual orientation, gender identity, national origin, age, disability, veteran status, or any other protected status prohibited under Federal, State, or local laws. All employment decisions are based on valid job‑related requirements.