Principal Scientist- NMR Spectroscopy

Shift: Monday through Friday, 8:00 AM - 4:30 PMAre you ready to work making the world a safer, healthier place? Join our mission to continuously move science forward; to innovate and advance all aspects of our business to improve the health and safety of our communities and lives.

This is a full-time, onsite, Principal Scientist – NMR Spectroscopy position located in Research Triangle Park (RTP) Morrisville, NC, Monday through Friday, 8:00 a.m.

- 4:30 p.m.Compensation: $110,000 - $120,000 per year

The salary for this position reflects a variety of factors. Compensation will be determined based on the candidate’s geographic location, relevant experience, education, skills, and alignment with internal equity. Market conditions, budgetary considerations, and organizational compensation guidelines may also influence the final offer.

Make an Impact. Build a Career.

Pace Life Sciences delivers a comprehensive suite of contract CMC development, CTM manufacturing, regulatory compliance, consulting, and facility support services to the pharmaceutical, biopharmaceutical, and gene therapy industries. Operating across a network of CDMO sites, GMP analytical testing laboratories, and manufacturing support centers, we partner with clients to efficiently advance programs from early development through commercialization.

Our experienced industry experts and continued investment in state-of-the-art facilities reflect our commitment to quality, speed, and reliability. United by a shared purpose, we bring meaningful value to patients, healthcare professionals, and health businesses worldwide by delivering services that support a safer, healthier future.

SUMMARY The Principal Scientist – NMR Spectroscopy is a senior technical leader responsible for biomolecular and small‑molecule NMR characterization within a fast‑paced CRO environment. This role provides expert‑level guidance in NMR spectroscopy and complementary analytical techniques to support structure confirmation, reference standard qualification activities, method development, and GMP/GLP‑aligned laboratory operations. The Principal Scientist serves as the technical authority for NMR instrumentation and data interpretation, leads complex investigations, supports client engagement and cross‑functional initiatives, and mentors scientists through innovation, scientific rigor, and collaboration.

ESSENTIAL FUNCTIONSLeads biomolecular NMR characterization of protein and oligonucleotide samples, including sample handling and preparation, assessment of suitability and stability, execution of multidimensional NMR experiments, and application of testing requirements and orthogonal characterization workflows to support structure confirmation, method development, and data interpretation.

Leads small‑molecule NMR analysis, including 1D and 2D experiments (¹H, ¹³C, COSY, HSQC, HMBC, NOESY, etc.), to support identity, purity, and structural confirmation of chemical entities.

Demonstrates knowledge of reference standard qualification requirements, including analytical study design and the use of NMR and orthogonal techniques such as mass spectrometry, HPLC, FTIR, UV‑Vis, TGA, DSC, and Karl Fischer.

Serves as the primary technical authority for NMR instrumentation, including method development, optimization, troubleshooting, calibration, and maintenance oversight.

Supports marketing strategy, service positioning, and client engagement by contributing technical insight and participating in client discussions to align analytical solutions with project objectives.

Partners with clients to address technical questions, propose analytical strategies, and support project planning and timelines.

Represents the analytical team in client meetings, audits, and internal leadership discussions, and communicates complex scientific concepts clearly and effectively.

Guides method transfers, validations, and cross‑functional scientific initiatives and contributes to resource planning and project prioritization.

Interprets and reviews complex analytical data, reports, and COAs to ensure scientific rigor, compliance, and regulatory readiness.

Leads technical investigations, OOS/OOT assessments, and CAPAs…