Senior Scientist​/Engineer: Advanced Oncology, Medical Devices Diagnostics

Senior Scientist / Engineer:
Advanced Oncology, Medical Devices, & Diagnostics

Intertwine LLC – Mt. Pleasant, South Carolina, United States – Science

At Intertwine Associates, we live by a simple promise:
We show up ready to work
. We partner with organizations across government, management, strategy, and technology to deliver operational efficiency and measurable impact—particularly in domains where foundational science meets real‑world execution. Learn more at .

Intertwine Associates is seeking a Senior Scientist / Engineer (Oncology / Medical Device Development) to support advanced research and development initiatives within the Advanced Research Projects Agency for Health (ARPA‑H). This role supports an ARPA‑H Program Manager leading ambitious, high‑risk, high‑reward programs focused on accelerating transformative health outcomes, particularly in oncology, diagnostics, and medical device innovation.

In this role, you will collaborate closely with the Program Manager and broader government and performer teams to help design, evaluate, and execute complex R&D programs spanning medical device hardware and software, biomedical engineering, cancer biology, and translational diagnostics. The position is well suited for scientists and engineers who thrive in dynamic environments and enjoy translating deep technical insight into program‑level impact.

• Serve as a senior scientific and technical advisor to the Program Manager, supporting the development and execution of new and existing ARPA‑H R&D programs
• Conduct rigorous evaluations of the current scientific and technical landscape across oncology, diagnostics, and medical device development
• Identify gaps, risks, and opportunities within research portfolios aligned with ARPA‑H mission objectives
• Monitor and assess performer progress against defined technical milestones and quantitative performance metrics
• Critically review complex scientific, engineering, and technical data using strong logical and analytical reasoning
• Read, synthesize, and distill large volumes of information into concise, executive‑ready briefings for technical and non‑technical audiences
• Support program execution through documentation, internal reporting, and coordination across multidisciplinary teams
• Perform programmatic support tasks including data collection, analysis, and preparation of internal reports and briefings
• Operate effectively both independently and as part of an integrated team supporting ongoing ARPA‑H efforts
• Travel within CONUS (~10–35%) to support program reviews, meetings, and stakeholder engagements

• Minimum 8 years of industry, applied research, or medical‑institution experience (e.g., biotechnology, biopharmaceutical, medical device, diagnostics, or advanced technology organizations)
• PhD in biomedical sciences or engineering, with preference for oncology, cancer biology, biomedical engineering, biochemistry, cell biology, mechanical engineering, chemical engineering, or related fields
• Strong written and verbal communication skills, with the ability to clearly convey abstract or highly technical concepts
• Proven ability to synthesize large volumes of complex information into actionable, decision‑ready insights
• High level of professional curiosity and comfort operating in fast‑paced, high‑pressure R&D environments
• Proficiency with PowerPoint and Excel, including rapid development of materials during live discussions
• Ability to obtain and maintain a federal Public Trust

• Hands‑on experience with medical device and/or diagnostic development, including hardware and/or software components
• Familiarity with regulatory considerations in diagnostics or medical devices
• Strong written and verbal communication skills, with the ability to convey complex concepts clearly and effectively
• Demonstrated ability to synthesize complex technical information into actionable insights
• Experience supporting senior leaders managing large or complex R&D portfolios
• Background spanning both basic and applied research
• Prior experience working with government agencies or federally funded R&D programs
• Experience…