Associate Scientist , Neuroscience

PTC Therapeutics is a global commercial biopharmaceutical company. For over 25 years our team has been deeply committed to a unified purpose:
Extending life's moments for children and adults living with a rare disease.

At PTC, we cultivate an inclusive culture where everyone feels valued, respected, and empowered. We welcome candidates from all backgrounds to join our team, fostering a strong sense of belonging.

Visit our website to learn more about our company and culture! Site:

Job Description

Summary:

The Associate Scientist I is responsible for conducting scientific experiments that support PTC's research and drug discovery efforts. In this role, the incumbent contributes to early-stage research activities aimed at the identification of New Chemical Entities (NCEs) and supports the advancement of research programs from initial screening hit identification through advanced lead optimization.

The Associate Scientist I is expected to accurately interpret experimental data and communicate findings in a timely and clear manner to their supervisor and the broader project team, ensuring alignment with program objectives and milestones.

In addition, the Associate Scientist I is responsible for ensuring compliance with all applicable regulatory requirements, company Standard Operating Procedures (SOPs), and established scientific and quality standards, as appropriate to the scope of their work.

• Under general supervision, design and execute experiments, then interpret and communicate results as a contributing member of multidisciplinary project teams.
• Apply relevant scientific principles and techniques to advance research objectives.
• Maintain thorough, accurate, and audit-ready laboratory notebooks in accordance with company standards.
• Stay current with state-of-the-art scientific principles, methodologies, and technologies relevant to the role.
• Independently troubleshoot experiments, including the design of appropriate controls and the generation of high-quality, interpretable data.
• Present experimental findings in internal forums and contribute to the preparation of manuscripts and other publications produced by the project team.
• Contribute to the development of patent applications as appropriate.
• Adhere to all environmental, health, and safety requirements.
• Support general laboratory operations, including stockroom upkeep, supply ordering, and other duties as assigned.
• Specific duties may also include, but may not be limited to, the following:
  • Support target deconvolution studies using a broad range of methodologies, including flow cytometry, ELISA, Western blot, RT-qPCR, primary immune cell isolation, and cell culture and handling.
  • Execute weekly cell-based screening assays to support hit-to-lead optimization efforts for early-stage discovery programs.
  • Maintain multiple cell lines - including thawing, passaging, and seeding - to support in vitro screening activities.
  • Upload and report experimental data in a timely manner and proactively communicate any delays or workflow changes to cross-functional team members.
  • Contribute to the design and optimization of new assays intended to identify additional hits.
  • Profile selected compounds across additional cell types and tissues to further characterize their mechanism of action.

• Experience with multi-color flow cytometry (sample preparation, staining, and analysis).
• Familiarity with the development and routine execution of reproducible, high-throughput assays.
• Hands-on mammalian tissue culture experience with excellent aseptic technique is required.
• Working knowledge of fundamental cell biology and molecular biology principles.
• Exceptional attention to detail, with strong time-management skills and the ability to balance competing priorities.
• Strong analytical, critical-thinking, and problem-solving capabilities.

* Minimum level of education and years of relevant work experience

• Bachelor's degree in a Biology scientific discipline, preferably Biology, Neuroscience or Immunology with a minimum of 4 years' experience, OR, Master's degree in a scientific discipline with a minimum of 1 years of relevant experience.

* Special…