Postdoctoral Position

Job Title

Using BRET system to image in vivo recording of neural activity in freely behaving animals

Postdoctoral Position available September 1, 2026 in Johnson Laboratory at Vanderbilt University. Innovative luminisence assay for neural activity:
The laboratory has developed innovative techniques using luminescence and/or BRET to monitor gene expression or protein–protein interactions non‑invasively. These luminescence techniques have significant advantages over fluorescence‑based and other methodologies. The current position is to further develop these state‑of‑the‑art luminescence techniques and apply them as non‑invasive monitors of neural synaptic activity in freely behaving mice (see our publication PMC
5476805). Our sensors will be applied to answer fundamental neurobiological questions in conjunction with optogenetics, including the neurobiology of circadian rhythms and reward pathways.

We will be collaborating with hotshot labs at Princeton and UCLA who specialize in mini scopes and optical technologies to record and control the intracellular signaling mechanisms that govern brain function and animal behavior.

Develop and refine state‑of‑the‑art luminescence and BRET techniques to monitor neural synaptic activity in freely behaving mice. Design and execute experiments that integrate optogenetics and imaging modalities. Analyze data to elucidate the neurobiology of circadian rhythms and reward pathways. Collaborate with laboratories at Princeton and UCLA on optical technologies and miniscope recording.

Postdoctoral candidate with a background in luminescence/fluorescence, microscopic imaging, neurobiology, and/or standard molecular genetic techniques. Prior experience with luminescence or BRET assays is desirable. Ability to work independently and as part of an interdisciplinary team.

Access to excellent facilities and collaborations within the Vanderbilt community, including the Vanderbilt Brain Institute and laboratories that study circadian clocks and sleep. Opportunity to work with leading laboratories in this field.

Interested applicants should contact Dr. Carl Johnson at carl.h.johnson.