Research Assistant - Hematology​/Oncology; Haake Cancer Lab

Job Summary

Perform under minimal supervision a wide variety of complex tasks requiring practical understanding of scientific techniques and advanced knowledge of scientific theory.

In the Haake Cancer Lab, we study the role of extracellular matrix (ECM) signaling during tumor initiation and evolution. ECM signaling via integrins is required for the survival of epithelial cells. As epithelial cells transform into carcinoma cells, the role of ECM and integrin signaling becomes more complex. In some contexts, such as lung cancer, we have shown that cancer cells exhibit constitutive, ligand‑independent activation of ECM receptors, and this signaling is required for tumor initiation.

Their role in the biology of carcinoma types remains poorly defined. Our current work is focused on understanding the biological factors that regulate integrin signaling in various tumor types, including kidney cancer.

• Experience with in‑vitro and animal based experiments

• Bachelor's Degree + 4 years of relevant work experience

• Under minimal supervision, plan, conduct and evaluate experiments and assays of varying complexity.
• Plan and coordinate experiments in conjunction with Principal Investigator.
• Understand and follow experimental protocols (may include animal handling, tissue culture, etc.).
• Record, compile, interpret, and communicate data/results.
• Follow University safety protocols (may include use of combustibles, radioactivity, toxic material, and/or carcinogens).
• Perform calculations involving molarity, % solutions, and serial dilutions.
• Prepare, operate and troubleshoot equipment in experimental procedures.
• Recommend equipment and supplies needed for research projects.
• Read and follow all equipment manuals.
• Maintain and repair equipment according to manufacturer and university guidelines.
• Ensure laboratory is prepared for experiments.
• Maintain inventories.
• Maintain sterile conditions as required.
• Prepare reagents.
• Assist PI in modifying procedures and techniques.
• Recognize problems and suggest solutions, assist in modifications.
• Recommend improvements to established techniques and/or protocols.
• Maintain personal knowledge of scientific trends through literature reviews, attendance at meetings, conferences and seminars.
• Provide appropriate written/oral documentation of experiments.
• Prepare research progress reports.
• Analyze and summarize test results.
• Prepare and give oral presentation of data as required.
• Assist in the effective operation of the laboratory.
• Train other employees.
• Supervise projects and/or personnel.

Vanderbilt Health is committed to fostering an environment where everyone has the chance to thrive and is committed to the principles of equal opportunity. EOE/Vets/Disabled.