Director, Distribution & Services

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life‑changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late‑stage clinical development for multiple indications. In March 2026 we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026.

Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic‑clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial.

In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early‑stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN
1701 (targeting Nav
1.7) and XEN
1120 (targeting Kv7), which are important pain targets. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

We are seeking a Director, Distribution and Services to join our team. This position will be responsible for developing, implementing, and leading the company’s U.S. distribution and services strategy, as well as overseeing trade channel operations. Key responsibilities include designing and managing distribution, logistics, services, and partner relationships to support the commercialization of Xenon’s neurology portfolio. The ideal candidate will have deep expertise in retail and specialty distribution, patient services programs, 3PL operations, and trade contract negotiation within specialty and non‑specialty pharmaceutical markets.

This role reports to the Senior Director of Market Access Strategy and Operations and is based out of Boston, MA, USA, in our Needham office. The level of the position will be commensurate with the candidate’s education and industry experience. Hybrid positions require a minimum of two onsite days per week.

• Develop and implement the overall trade and distribution strategy for Xenon’s commercial portfolio, ensuring efficient and compliant product flow from manufacturing through to patients.
• Oversee selection, onboarding, and management of trade partners including 3PL providers, retail pharmacies, specialty distributors, specialty/digital pharmacies, and wholesalers.
• Lead trade agreement development, contracting, and performance management, including service level, fee‑for‑service, and distribution network optimization.
• Partner with Finance, Supply Chain, and Commercial teams to forecast demand, monitor commercial channel inventory, and identify trends impacting availability.
• Ensure compliance with federal and state distribution regulations (DSCSA, PDMA, licensing, and other requirements).
• Serve as Xenon’s subject matter expert for trade operations during product launches, ensuring seamless alignment across the organization.
• Manage relationships with trade partners to optimize cost, performance, and customer satisfaction.
• Develop and track key performance indicators and dashboards for distribution, inventory, and trade partner…