Manager​/Senior Manager, Clinical Supplies

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026.

Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial.

In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN
1701 and XEN
1720 (targeting Nav
1.7) and XEN
1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

We are seeking a Manager/Senior Manager, Clinical Supplies
title to join our team. The Manager/Senior Manager, Clinical Supplies will be responsible for ensuring that the labeled clinical supplies are provided to clinical sites on time and in accordance with clinical trial protocols and applicable regulatory requirements. This role includes the management and oversight of planning, forecasting, packaging, labeling, distribution and return of clinical supplies, and collaborates closely with CMC and Supply Chain teams as well as with key internal stakeholders such as Clinical Operations, Regulatory Affairs and Quality Assurance.

This position reports to the Senior Director, Clinical Supplies and will be based out of Boston, MA, USA in our Needham office. The level of the position will be commensurate with the candidate’s education and industry experience. Hybrid positions require a minimum of two onsite days per week. On-site positions require up to five on-site days per week.

• Develop study-specific Investigational Product Supply Plans and contribute to Pharmacy Manuals and supply-related training/instructional materials.
• Manage supply planning/forecasting to ensure alignment with study activity and timelines.
• Perform supply accountability tracking and ensure that all Master, Pharmacy and Subject logs are appropriate. Ensure all investigational product supply activities are documented in the Trial Master File.
• Monitor inventory levels at sites throughout the trial in order to proactively avoid potential issues.
• Collaborate with study teams and external vendors to assure proper distribution of supplies to study sites.
• Coordinate procurement, temperature excursions, and…