Principal​/Senior Systems Engineer; Microsoft Copilot AI

Who We Are:

Xenon Pharmaceuticals (NASDAQ:

XENE) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we anticipate submitting a New Drug Application to the Food and Drug Administration in the third quarter of 2026.

Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial.

In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN
1701 (targeting Nav
1.7) and XEN
1120 (targeting Kv7), which are important pain targets. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

We are seeking a Principal/Senior Systems Engineer
, to join our team. This role will serve as the Technical Lead for Generative AI and Collaboration Tools. The Principal/Senior Systems Engineer will serve as the platform owner for Microsoft 365 and Copilot AI. The successful candidate will also play a hands‑on role with technical support escalations, requiring frequent interactions with vendor support and consultants on behalf of the team.

Initial focus will be on Copilot governance, Microsoft 365 platform optimization, and secure collaboration capabilities. During this period of rapid growth, this role may be assigned additional responsibilities (beyond Microsoft platforms and the core responsibilities described above). This position reports to the Senior Director, End User Solutions and will be based onsite in Needham, MA, USA. The level of the position will be commensurate with the candidate’s education and industry experience.

• Serve as the technical system owner for the Microsoft 365 platform (including Copilot AI, Office Apps, Exchange, Teams, SharePoint, etc.).
• Continuously review the latest Copilot releases. Test and evaluate Frontier offerings to determine fit for use. Promote adoption of agentic features within Microsoft 365 (e.g. SharePoint, Teams, Office Apps, etc.) and educate IT Admins. Lead End User training sessions to improve the organization’s productivity.
• Establish AI Agent governance, standards, and policies, with Agent
  365, Copilot Studio, and Purview.
• Partner with business stakeholders to develop Copilot Agents, SharePoint Agents, and Power Platform Apps/Flows to deliver unique solutions.
• Standardize modern ways of working across the company centered on Teams, One Note, Loop, & Planner.
• Implement secure external collaboration controls in SharePoint, including the establishment of sensitivity labels and retention policies in Purview.
• Partner with stakeholders to design SharePoint sites to improve communication and collaboration.
• As the primary Email Administrator, partner with the Information Security team on improving posture and controls to prevent business email…