Principal Scientist – AI-Reasoning Drug Discovery

At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, and solutions are personal.

Through our expertise in Innovative Medicine and Med Tech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.

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Data Analytics & Computational Sciences

Data Science

Scientific/Technology

Cambridge, Massachusetts, United States of America, New Brunswick, New Jersey, United States of America, Raritan, New Jersey, United States of America, Spring House, Pennsylvania, United States of America, Titusville, New Jersey, United States of America

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

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Johnson & Johnson Innovative Medicine (J&J IM) is recruiting for the role of "Principal Scientist – AI-Reasoning for Drug Discovery".

The primary location for this role is Spring House, PA.

• Horsham, Pennsylvania,
• Cambridge, Massachusetts,
• New Brunswick, Raritan or Titusville, New Jersey

J&J IM develops treatments that improve the health and well-being of people worldwide. Research and development areas encompass oncology, cardiovascular and retina disorders, immunology, and neuroscience. Our goal is to help people live longer and healthier lives. We have produced and marketed many first-in-class prescription medications and are poised to serve the broad needs of the healthcare market – from patients to practitioners and from clinics to hospitals.

To learn more about J&J IM, please visit

The DDSAI-OCMO team is seeking a visionary Principal Scientist to architect an AI-Reasoning platform to support Translational Safety decision making in drug discovery and development. You'll pioneer the development of innovative reasoning platform that scientists can access through Large Language Models (LLMs) and agentic systems, harnessing Multimodal Scientific data across Discovery, Preclinical, Clinical, and RWE domains, harnessing large scale datasets spanning scientific literature, omics, biomolecular knowledge, and manufacturing processes to fundamentally transform how we bring therapeutics to patients.

Your innovations in areas such as multimodal reasoning, agent adaptability and uncertainty, memory architecture, and motivation frameworks will directly compress discovery timelines and accelerate promising therapeutics from hypothesis to clinical trials.

• Pioneer breakthrough multimodal AI systems that synthesize scientific data into actionable scientific insights which accelerate drug discovery
• Architect next-generation agent memory systems that establish how AI retains knowledge and makes context-aware decisions, creating persistent intelligence that evolves across the entire discovery-to-development pipeline
• Define the future of AI reliability in R&D by…