Principal ScientistSenior Principal Scientist, Material Science & Engineering at Bristol Myers

Working with Us

Challenging. Meaningful. Life-changing. Those arent words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here uniquely interesting work happens every day in every department. From optimizing a production line to the latest breakthroughs in cell therapy this is work that transforms the lives of patients and the careers of those who do it.

Youll get the chance to grow and thrive through opportunities uncommon in scale and scope alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits services and programs that provide our employees with the resources to pursue their goals both at work and in their personal lives. Read more:
Drug Product Development team is committed to CMC design development and commercialization of innovative drug products to improve patient lives. We leverage the best people collaboration and cutting-edge innovation to achieve this commitment. BMSs internal engine of innovation includes unrivaled industry leading expertise in CMC development of small molecules protein biotherapeutics protein degraders and other therapeutic modalities. We collaborate closely with our colleagues in R&D and Commercial to design our drug products.

Here youll get the chance to grow and thrive through opportunities that are uncommon in scale and scope.

As a Principal or Senior Principal Scientist in the Drug Product Development - Materials Science and Engineering Group the main responsibilities will be developing understanding of the material options for novel drug candidates and driving the selection of commercial materials. The candidate is expected to apply biopharmaceutics physical chemistry and engineering principles to achieve these goals. Primary activities and responsibilities will include:

• Screening for polymorphs of neutral molecules salts and cocrystals to support material selection
• Perform solid state material characterization of novel materials
• Perform solid state physical and chemical stability assessments on selected lead materials
• Develop understanding of the polymorph landscape and thermodynamic relationships between polymorphic forms leveraging automated and manual experimentation as well as connecting with predictive modeling
• Connect selection of materials into the manufacturing stability and performance of drug products
• Provide leadership and supervision to scientific staff. Develop coach and mentor others.
• Participate in and lead cross-functional materials teams for novel drug candidates to drive materials strategy at the interface of drug substance and drug product.

It is expected that the candidate will work with a broad range of materials such as crystalline and non-crystalline APIs including small molecules peptides oligonucleotides as well as drug product intermediates that will be used in the design of robust oral and injectable drug product formulations.

This role may be appointed at the Principal Scientist or Senior Principal Scientist level. Candidates with demonstrated experience and expertise will be considered for the appropriate level.

• Principal Scientist:
  Pharmaceutics Pharmaceutical Science Pharmaceutical Chemistry Organic Chemistry Chemical Engineering or related field with 46 years of industry experience or MS with 69 years or BS with 912 years
• Senior Principal Scientist:
  Ph.D. in a relevant field (e.g. physical chemistry materials/pharmaceutical science chemical engineering) with 68 years of industry experience or MS with 912 years or BS with 1215 years
• Excellent problem-solving skills with a strong background in biopharmaceutics and pre-formulation are required.
• Hands‑on experience in laboratory experimentation and expertise in solid state characterization techniques such as XRD BET moisture sorption thermal techniques such as TGA DSC and hot stage microscopy optical and electron microscopy vibrational spectroscopy and chromatography techniques is preferred.
• Experience with polymorph screening and salt/form selection is required.
• Familiarity with high-throughput experimentation and data analysis is desired.
• Experience with complex molecules such as millamolecules oligonucleotide peptides and proteins is desired.
• Experience with direct management and with cross-functional team leadership is also desired.
• A demonstrated record of scientific accomplishment laboratory experimentation publication and presentation is required.

The individual will effectively interface and collaborate across drug substance drug product and analytical development teams. The individual must have demonstrated ability to identify and solve problems. Outstanding oral and written communication skills with the ability to provide technical input and scientific leadership are required. This position requires employees to work safely at laboratory scale with…