Postdoctoral Research Fellow

Job Summary

The salary range for this postdoctoral position is $70,000 to $71,750 annually.

The Vazquez-Garcia Lab at Massachusetts General Hospital, Harvard Medical School, and the Broad Institute is seeking exceptional candidates for a postdoctoral position in interdisciplinary research focused on the fundamental principles of somatic evolution and immune surveillance in cancer.

Key objectives include studying cellular dynamics in tumors using AI/ML, single-cell genomics, and imaging, integrating large clinical datasets and experimental models to understand genomic adaptations that influence tumor behavior and to identify biomarkers for therapeutic response.

• Design, train, and evaluate cutting-edge AI and statistical models using large patient datasets.
• Build robust pipelines for large-scale data processing and benchmarking across modalities.
• Collaborate closely with cancer biologists, clinicians, and computational researchers to generate testable hypotheses and interpret findings.
• Perform exploratory research in a fast-paced setting with potential impact on patients.
• Contribute to the development of high-quality, reusable, open-source software.
• Publish research in top-tier journals and present at major conferences.
• Help foster a collaborative lab environment by advising and supporting junior team members.

• Ph.D. (or near completion) in Computational Biology, Computer Science, Physics, Mathematics, Statistics, or a related quantitative discipline.
• Demonstrated proficiency in Python, R, and/or other scientific computing languages.
• Proven productivity through peer-reviewed publications.
• Excellent written and verbal communication skills.
• Ability to work independently and as part of a collaborative team.
• Strong organizational skills and attention to detail.

• Experience working with high-dimensional, multi-modal omics data and clinical data.
• Strong background in advanced statistical modeling and/or modern machine learning approaches (e.g., transformers, foundation models, generative modeling, interpretable AI).
• Knowledge of cancer biology, immunology, or molecular biology.
• Familiarity with cloud computing and workflow management (e.g., Nextflow, Snakemake).
• Experience with version control and software engineering practices.
• Interest in contributing to open-source bioinformatics software.

Onsite – 149 Thirteenth Street, Building 149, Boston, MA.

Submit a CV, representative publications or preprints, a statement of prior research and future interests, and contact information for three references to Ignacio Vazquez‑Garcia, PhD at ivazquez-garciavard.edu
.

The General Hospital Corporation is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, or other status protected under law. We will provide reasonable accommodation for applicants with disabilities in the job application and interview process.