Engineer, Systems Engineer

Senior Bioprocess Engineer

Location: On-site, New Haven, CT Company: Bexorg ()

Bexorg is a Tech Bio company pioneering a completely new way to understand and treat neurodegenerative diseases such as Alzheimer's and Parkinson's. Building on the landmark 2019 Nature paper by Zvonimir Vrselja and Nenad Sestan demonstrating that mammalian brain cellular functions can be partially restored hours after death, Bexorg uses donated, intact human brains to develop transformative therapeutics for the most challenging diseases affecting humanity.

Headquartered in New Haven, CT, Bexorg has raised $42M to date and is already generating substantial revenue through collaborations with leading biopharma companies. Our flagship platform,
Brain Ex
, is the world's first system to perfuse fresh, whole postmortem brains through their intact vasculature — restoring and maintaining cellular biology, vascular reactivity, CSF circulation, and an intact blood‑brain barrier — and is the foundation of an active CNS therapeutics pipeline that includes a Phase 1 program in Alzheimer's disease.

We are seeking a Senior Bioprocess Engineer to own the iterative engineering of the Brain Ex whole‑brain perfusion platform. Brain Ex is a proprietary closed‑loop physiological system that functions as an artificial cardiovascular, pulmonary, and renal system for an intact human brain — with custom hardware and software regulating circulatory volume, cerebral blood flow, systolic pressure, pH, dissolved gases, temperature, metabolites, and drug dosing throughout each run.

You will be responsible for continuously improving the performance, reliability, features, and automation of the Brain Ex platform: tightening closed‑loop control, extending run duration (currently up to 24 hours, with active work toward multi‑day and ultimately two‑week runs), improving reproducibility across runs, and expanding the experimental capabilities the rig can support.

This is a hands‑on, senior technical role for someone who wants to own and evolve a first‑of‑its‑kind bioprocess system in close collaboration with surgeons, perfusion technicians, software engineers, and drug discovery scientists.

• Own the end‑to‑end bioprocess engineering of Brain Ex perfusion rigs — from subsystem‑level redesigns through deployment of new revisions on the production fleet.
• Specify, integrate, and continuously improve the rig's hardware components: peristaltic and centrifugal pumps, valves, manifolds, oxygenators, hemofiltration / dialysis modules, heat exchangers, reservoirs, bubble traps, and inline sensors.
• Architect and refine the closed‑loop physiological control of:
  • Cerebral blood flow and systolic pressure profiles, including pulsatility
  • Circulatory volume and fluid balance
  • Temperature
  • pH, dissolved gases (pO₂, pCO₂), and gas exchange
  • Hemofiltration, dialysis, and metabolite/waste management
  • Synthetic blood (oxygen‑carrier perfusate) handling, conditioning, and recirculation
  • Compound dosing concentrations, infusion timing, and arterial/venous sampling cadence
• Drive design improvements that increase run duration, reduce failure modes, and expand the experimental envelope of the platform (e.g., new sampling capabilities, regional perfusion control, modeling of pathophysiological states such as ischemia/stroke).

• Develop robust automation for the full perfusion workflow: rig setup and priming, calibration, run initiation, steady‑state operation, perturbation and dosing protocols, monitoring, fault detection, and safe shutdown.
• Implement and maintain the supervisory control software that coordinates pumps, valves, gas mixers, dialysis, sensors, and dosing — including PID/cascade control loops, state machines, and safety interlocks.
• Build real‑time monitoring, alarming, and operator interfaces so that runs can be supervised reliably with minimal technical intervention.
• Collaborate with software engineers to integrate the rig with higher‑level orchestration, telemetry pipelines, the AWS data lake, and LIMS/ELN tooling.

• Rapidly prototype, test, and iterate on…