Postdoctoral Associate in Mitochondrial Biology​/Genetics

We are seeking a motivated postdoc to join our growing team in the Yale University Department of Genetics. Our lab uses experimental and computational methods to investigate cellular and health consequences of mitochondrial genome mutations, and their modifiers (e.g. Lake et al, Nature, 2024).

We are recruiting a postdoc to lead innovative projects investigating how the mitochondrial genome and mtDNA mutations shape cellular function, human health, and disease. Using cutting‑edge approaches, the successful candidate will identify pathogenic variants, uncover factors that modify their effects across individuals and cell types, and define interactions between mitochondrial and nuclear genomes. Projects will involve developing and applying new technologies to measure mtDNA variation and dynamics, performing high‑throughput screens, and building novel cellular models to reveal mechanisms of mitochondrial genome dysfunction.

The lab is located in the Yale School of Medicine which offers an outstanding training environment for postdoctoral scientists, with state‑of‑the‑art research facilities and vast resources to support professional development. For more information about our lab, past publications and our research please see our website: https://(Use the "Apply for this Job" box below)./

• Generate and characterize novel cellular models of mitochondrial genome dysfunction using genome‑editing and related technologies
• Develop and apply new tools to study mtDNA mutations, copy number, and dynamics
• Characterize the cellular and mitochondrial consequences of mtDNA mutations using molecular, imaging, and functional assays
• Prepare high‑impact manuscripts for publication and conference presentations
• Attend and present at lab meetings, journal clubs, and departmental seminars
• Contribute to the mentoring of students and junior scientists in the lab
• Assist in the preparation of grant proposals
• Maintain experimental records and protocols, and support lab operations as needed
• Positively contribute to lab culture

The lab has a strong emphasis on mentorship and values the opportunity to train future leaders in mitochondrial genomics. The PI will work with the successful candidate to develop and implement a mentorship plan tailor‑made for their goals and interests. Mentorship will be provided for fellowship applications, manuscript writing, presentations, and independence.

The successful candidate will gain access to a range of career development opportunities s includes seminars from internationally renowned researchers and Meet the Speaker lunches, and professional development and networking activities via the Yale Postdoctoral Association and Yale Office for Career Strategy.

Candidates should have or be close to obtaining a PhD in genetics, mitochondrial biology, molecular and cellular biology, or a related field.

Experience with cell culture and molecular biology techniques is required. Experience with one or more of the following is desired: CRISPR/genome editing methods, mitochondrial assays, live‑cell imaging, development of cellular models, or functional characterization of genetic variants.

The ideal candidate will also demonstrate:

• Drive and initiative, and track record of impactful research outcomes
• Manuscripts published in peer‑reviewed journals
• Ability to work both independently and as part of a team
• Eagerness to learn and establish new methods, and good problem‑solving skills
• Excellent communication skills, both written and verbal
• Desire to contribute to the mentorship of students and junior scientists in the lab

This is a full‑time, in‑person position at Yale in the vibrant city of New Haven, Connecticut, with a competitive salary starting from $68,500 a year and access to a range of benefits. The start date is negotiable, but can be as soon as fall 2026.

Please email the following to Dr. Nicole Lake e: (1) a cover letter summarizing your experiences, research interests, and career goals, and why you are interested in pursuing a postdoc in our lab, (2) your CV, including contact details of three references, and (3) when you are available to start, using the subject Postdoc Application - Yale Lake Lab.

Interested applicants are encouraged to submit their application promptly. For any questions about the position, please email nicole.lake.

Nicole J. Lake, Ph.D.
Assistant Professor of Genetics
Yale Center of Genomic Health
Yale University School of Medicine