Research Investigator

Position Summary

We are seeking a highly motivated, collaborative scientist to join the Discovery Chemistry team at our New Haven, CT laboratories. The successful candidate will contribute to the design, synthesis, purification, and analytical characterization of novel bioconjugates that support our industry-leading extracellular targeted protein degradation (eTPD) platform. This position offers the opportunity to work in state-of-the-art laboratories and collaborate closely with multidisciplinary teams spanning biology, biochemistry, toxicology, and pharmacology to advance innovative preclinical drug discovery programs.

Key Responsibilities

* Maintain a daily on-site laboratory presence and actively contribute to team-based research activities.

* Design, develop, optimize, and execute site-specific conjugation strategies for proteins and other biomolecules using a variety of chemical methodologies at milligram-to-gram scale.

* Purify and characterize starting materials, intermediates, and final conjugates using techniques including TFF, FPLC, HPLC, LC-MS, BLI, and related analytical methods.

* Serve as a subject matter resource for critical laboratory instrumentation, ensuring proper operation, maintenance, and troubleshooting.

* Develop experimental strategies, establish project timelines, and recommend efficient workflows to support program objectives.

* Maintain accurate, detailed, and timely experimental documentation in electronic laboratory notebooks (ELNs).

* Analyze, interpret, and present scientific data at team meetings and contribute to project strategy discussions.

* Collaborate effectively across cross-functional teams in a dynamic and fast-paced research environment.

Qualifications

Required

* Ph.D. in Organic Chemistry, Chemical Biology, Medicinal Chemistry, or a related discipline; alternatively, an M.S. degree with a minimum of 3 years of relevant industry experience.

* Hands-on experience with protein purification and analytical characterization techniques such as TFF, FPLC, HPLC, LC-MS, BLI, or related methodologies.

* Strong analytical, technical, and problem-solving skills, including demonstrated success in troubleshooting chemical reactions, conjugation processes, and analytical workflows.

* Ability to manage multiple priorities, work independently, and contribute effectively within multidisciplinary teams.

* Excellent written, verbal, and interpersonal communication skills.

Preferred

* Experience with antibody, protein, or peptide conjugation chemistry.

* Experience supporting biologics, bioconjugate, ADC, or protein degradation drug discovery programs.

* Familiarity with characterization and quality assessment of protein-based therapeutics and bioconjugates.