Principal Embedded Software Engineer

Principal Embedded Software Engineer

Fluidic Controls & Instrumentation — Brain Ex Platform

Bexorg, Inc.
On-site, New Haven, CT

Bexorg is on a mission to move medicine forward by developing technologies that improve and extend human life.

As a fast-growing biotech company, we operate at the intersection of scientific rigor and startup velocity—where strong execution, innovation, collaboration, and accountability are critical to our success.

Our work combines cutting‑edge neuroscience, AI, and translational science to accelerate discovery and development for central nervous system (CNS) diseases.

At Bexorg, we value individuals who are proactive, adaptable, intellectually curious, and energized by solving complex problems in a highly collaborative environment.

We are seeking a Principal Embedded Software Engineer to own the electronics, firmware, and real‑time control that make the Brain Ex whole‑brain perfusion platform work. Brain Ex is a proprietary closed‑loop physiological system that functions as an artificial cardiovascular, pulmonary, and renal system for an intact human brain — custom hardware and software regulating circulatory volume, cerebral blood flow, systolic pressure and pulsatility, pH, dissolved gases, temperature, metabolites, and drug dosing throughout each run.

This is deliberately not a pure‑software job. We are looking for a genuine generalist — someone who writes production firmware in the morning, scopes a noisy pressure transducer signal after lunch, redesigns a fluidic manifold in CAD, and has a prototype printed or sent out for machining by the end of the week. You will be the person who takes a control problem from physiological requirement to schematic, to board, to firmware, to the Python supervisory layer above it, to a validated rig revision running on the production fleet.

You will report into the Technology team and work shoulder‑to‑shoulder with bioprocess engineers, surgeons, perfusion technicians, software engineers, and drug discovery scientists. Current priorities include tightening closed‑loop control, extending run duration (today up to 24 hours, with active work toward multi‑day and ultimately two‑week runs), improving reproducibility across donors, and expanding the experimental envelope the rig can support.

• Embedded Firmware & Real‑Time Control
  • Own the embedded stack on Brain Ex rigs — bare‑metal and RTOS firmware (C/C++ on ARM Cortex‑M; FreeRTOS or Zephyr) plus embedded Linux supervisory layers — from architecture through field deployment and versioned rollout across the fleet.
  • Implement the control loops that hold the brain in physiological range: PID, cascade, and feed forward control of pressure, flow, pulsatile waveform generation, temperature, pH, and gas exchange, with anti‑windup, gain scheduling, bumpless transfer, and graceful degradation.
  • Build the state machines and interlocks governing rig setup and priming, calibration, run initiation, steady‑state operation, perturbation and dosing protocols, fault detection, and safe shutdown — including watchdogs, sensor‑plausibility checks, and defined safe states for every credible failure mode.
  • Guarantee determinism where it matters: loop‑rate budgeting, interrupt and DMA design, jitter measurement, and instrumented timing so control behavior is provable rather than assumed.
  • Own the field buses and device integration — I²C, SPI, UART, RS‑485/Modbus RTU, CAN/CANopen, EtherCAT or equivalent, USB, and Ethernet — across pumps, gas mixers, mass flow controllers, proportional valves, dialysis modules, and analyzers.
• Instrumentation, Electronics & Sensing
  • Design and bring up custom electronics: schematic capture and PCB layout (Altium, KiCad, or similar), analog front ends for bridge and ISE sensors, 16–24‑bit ADC selection, isolation, EMI and grounding strategy, connectorization, and harnessing for a wet, salt‑spray‑adjacent lab environment.
  • Integrate and characterize the sensor suite: pressure transducers, ultrasonic and Coriolis flow meters, thermocouples/RTDs, pH and blood‑gas analyzers, inline optical O₂ and metabolite sensors, bubble detectors, and load cells for gravimetric…