Medical Director, Neuroscience – US Medical Affairs

Job Description:

At Johnson & Johnson,we believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented, treated, and cured,where treatments are smarter and less invasive, and solutions are personal.

Through our expertise in Innovative Medicine and Med Tech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow,and profoundly impact health for humanity.

Learn more at  As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

Job Function:
Medical Affairs Group Job Sub Function:
Medical Affairs Job Category:
People Leader

All Job Posting Locations:
Titusville, New Jersey, United States of America

We are searching for the best talent for a Medical Director, Neuroscience – US Medical Affairs located in Titusville, NJ.

About Neuroscience Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science‑based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Our Neuroscience team tackles the world’s toughest brain health challenges including multiple sclerosis, Alzheimer’s disease, Parkinson’s disease, myasthenia gravis, epilepsy, major depressive disorder, bipolar disorder, schizophrenia, and autism.

This patient‑focused team helps address some of the most complex diseases of our time. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at

The Medical Director, Neuroscience – US Medical Affairs is responsible for the medical strategy and integrated evidence plan for Spravato (esketamine) and performs the full range of Medical Director activities for the asset.

The role leads the Integrated Evidence Team (IET) for Spravato, ensuring a strong, strategically aligned scientific strategy and its execution through evidence generation and impactful dissemination.

The role works closely with partners across US and Global Medical Affairs, RWV&E, R&D, Biostatistics, and Commercial teams.

If you are a strategic problem solver energized by shaping the medical strategy for a differentiated treatment in mood disorders, this is an opportunity to make a meaningful impact.

You will be responsible for:

• Lead the coordinated medical strategy and the Integrated Evidence Team (IET), including development and maintenance of a current, strategically aligned, annually updated Integrated Evidence Generation Plan (IEGP).
• Provide medical review and approval for Spravato medical, scientific and promotional content as a Medical Affairs reviewer.
• Represent Medical Affairs on the Spravato Label Working Group and Safety Management Team, contributing medical judgment on labeling and safety.
• Coordinate collaboration with cross‑functional partners, including MSL team leaders, RWV&E, Field V&E, Strategic Customer Group (SCG), Marketing brand teams, Medical Information, and other Commercial and IET partners.
• Manage the Spravato publication plan and support development of abstracts and manuscripts as an author or reviewer, with a focus on efficacy, outcomes and safety analyses.
• Serve as the SME across the organization for projects, external communications, and other efforts as needed.
• Support payer‑related materials and evidence needs to advance market‑access efforts.
• Serve as Study Responsible Physician/Scientist for esketamine (ESK) studies conducted within Medical Affairs—including Phase IIIb/IV, post‑marketing requirement studies, registries, real‑world evidence, and collaborative studies—providing study design, protocol development, statistical analysis planning, medical/data monitoring, and overall medical oversight.
• Contribute to regulatory submissions and interactions with Health Authorities (particularly the FDA) for Spravato, and help ensure post‑marketing…