Sr Director, Commercial Finance New

Definium Therapeutics is a late-stage clinical biopharmaceutical company and our mission is to forge a new era of psychiatry by applying scientific rigor to psychedelics, with the goal of developing accessible treatments that unlock healing at scale.

Our leadproductcandidate,lysergidetartrate(our proprietary orally disintegrating tablet form oflysergide(LSD) D-tartrate),represents a highly differentiated, potential best-in-class opportunity for patients suffering from generalized anxiety, major depressive disorder, and posttraumatic stress disorder. Our early stage pipeline includes DT402, the R-enantiomer of MDMA and is under development to target the core symptoms of autism spectrum disorder (ASD), specifically addressing social communication challenges.

Guided bythe recognition that patients deserve more than better, Definium is relentlessly advancing a new generation of therapeutics intended to addresstheunderlying causes of psychiatric and neurological disorders. By turning evidence into impact, Definium aims to change the trajectory of today’s mental health care crisis and enable a healthier future. Headquartered in New York, Definium Therapeutics trades on Nasdaq under the symbol DFTX.

Together we are moving psychiatry forward—beyond better, into a boundless future. Join us!

We are seeking an experienced and highly strategic Senior Director, Commercial Finance to lead the Commercial Finance function. This individual will serve as a key business partner to the Commercial Leadership team, providing financial leadership and decision support as the company evolves toward commercialization.

The ideal candidate combines deep pharmaceutical or biotechnology commercial finance experience with the ability to operate effectively in a fast-paced, resource-conscious environment. This role will help establish the commercial finance infrastructure, processes, forecasting methodologies, performance metrics, and strategic decision-making capabilities needed to support a high-growth organization.

Reporting to the VP, Finance & Strategy, the Senior Director will play a critical leadership role in long-range planning, revenue forecasting, launch readiness, resource allocation, and business performance management.

• Serve as the primary finance business partner to Commercial leadership, providing strategic financial guidance and decision support
• Lead commercial financial planning processes, including annual budgets, quarterly forecasts, long-range planning, and scenario analysis.
• Develop and maintain revenue forecasts, demand models, and commercial planning assumptions, partnering with Commercial Accounting on gross-to-net methodologies and financial implications of pricing, reimbursement, and market access strategies
• Partner with Commercial leadership to assess commercial readiness, evaluate infrastructure and investment priorities, and support sales force sizing, territory planning, and resource optimization
• Support product strategy, commercialization planning, and strategic initiatives through financial modeling, business case development, ROI analysis, competitive assessments, and market opportunity evaluations
• Develop KPIs, dashboards, and reporting tools to track launch preparedness and commercial performance, providing actionable insights to support decision-making
• Prepare analyses and presentations for Executive Leadership, Board meetings, and strategic planning discussions
• Establish and scale the commercial finance function, including processes, systems, and best practices to support business growth
• Partner with the broader FP&A organization to ensure alignment and consistency across corporate planning activities

• Bachelor's degree in Finance, Accounting, Economics, Business, or a related field; MBA, CPA, or CFA preferred
• Minimum 10 years of progressive finance experience, including significant FP&A and commercial finance leadership experience
• Experience supporting commercial organizations within the pharmaceutical, biotechnology, or life sciences industries
• Experience supporting commercial readiness activities, product launches, revenue forecasting, and market access planning
• Strong…