Manager, Clinical Pharmacology

Role Summary

Exciting opportunity in Clinical Pharmacology! Our Clinical Pharmacology Team is looking for a Manager to support the internal medicine portfolio. The team champions innovative Model‑Informed Drug Development (MIDD) for efficient drug development and robust decision‑making. The role is an internal medicine portfolio lead, providing clinical pharmacology and MIDD components of clinical plans and delivering expertise to project teams and regulatory interactions.

• Act as Clinical Pharmacology representative on Clinical Sub Team, Development Team and other multifunctional teams.
• Provide leadership, expertise, and deliverables of clinical pharmacology for assigned projects.
• Design and execute clinical pharmacology plans and implement best practices.
• Work closely with other disciplines to ensure sufficient preclinical PK/PD knowledge and establish predictive model structure prior to FIH.
• Plan and oversee clinical pharmacology aspects at the project level, including clinical development plan, PK/PD analyses, PK/immunogenicity/biomarker strategies.
• Plan and oversee study level activities such as protocol authoring, clinical phase oversight, and reporting.
• Work with clinicians and statisticians to ensure appropriate dose‑range finding strategies to determine optimal doses and regimens.
• Ensure appropriate design and implementation of an End‑to‑End MIDD plan that conforms with best practices.
• Use innovative analytical methods to integrate PK, PD, patient characteristics, and disease states for optimal dosing and study design.
• Contribute to regulatory documents (briefing documents, regulatory queries, Investigator’s Brochures, IND, NDA/MAA, etc.).
• Stay abreast of literature, regulatory guidelines, and internal SOPs.
• Influence the external environment through publications, presentations, and representation at scientific societies and industrial consortiums.

• Strong quantitative skills and expertise in mechanistic PK/PD modeling, systems pharmacology, literature meta‑analyses, population modeling, and clinical trial simulations using NONMEM, R, etc.
• MD, PhD, or equivalent training/experience in pharmacokinetics, pharmacometrics, clinical pharmacology, engineering, or related discipline.
• 0+ years of industry experience (Pharmaceutical approach). PharmD or equivalent experience, 2+ years of industry experience.
• Excellent written and verbal communication skills.
• Demonstrated presentation skills and ability to work in global team meetings across time zones.
• Broad leadership experience, ability to influence and collaborate with peers to achieve meaningful outcomes and create business impact.

• Eligible for relocation package:
  Yes.
• Eligible for employee referral bonus:
  Yes.
• Work location assignment:
  Hybrid.
• The annual base salary ranges from $ to $.
• Eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 15.0% of base salary.
• Eligibility to participate in share‑based long‑term incentive program.
• Comprehensive benefits: 401(k) with matching contributions, additional retirement savings contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, health benefits (medical, prescription drug, dental, vision). Learn more at Pfizer Candidate Site – U.S. Benefits: usca
• Pfizer compensation structures are aligned based on location of hire; the US salary range does not apply to Tampa, FL or outside the United States.
• Required:
  
  Permanent work authorization in the United States.
• U.S. work visa sponsorship (such as TN, O‑1, H‑1B, etc.) is not available for this role now or in the future.

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer complies with all applicable nondiscrimination laws and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E‑Verify employer.

This position requires permanent U.S. work authorization.