Group Leader, Immune Cell Reprogramming

Biohub is the first large-scale initiative bringing frontier AI models, massive compute, and frontier experimental capabilities under one roof. We’re building a general-purpose system to accelerate scientific discovery, integrating frontier AI models, biological foundation models, and lab capabilities, with the ultimate goal of curing disease. Our technology powers scientists around the world, translating AI capabilities into tools that accelerate research everywhere.

Our immune cell reprogramming team integrates foundational research on immunology and disease biology with AI‑modeling to develop engineered cells that harness our own immune system to detect and treat early signs of age‑related diseases, like cancer, Alzheimer’s, and Parkinson’s. These technologies will enable precise, context‑dependent therapeutic responses only when and where it is needed.

Biohub NY seeks to recruit an outstanding scientist to serve as Group Leader (equivalent to a Principal Investigator in academia), leading our Immune Cell Reprogramming research program.

The Group Leader will build, lead, and oversee a small research team focused on elucidating immune cell mechanisms in disease at the cellular and molecular levels, with the ultimate goal of developing novel immunotherapies. The program should include a strong research emphasis on T cell exhaustion, including strategies to understand, prevent, and/or reverse this process.

Ideal candidates will demonstrate a strong track record of scientific achievement, along with a commitment to collaboration in a highly interdisciplinary environment.

• Identify, recruit, manage, and mentor cell reprogramming lab members working under your supervision.
• Lead and actively participate in an innovative, vigorous, and collaborative research program aligned with the mission of CZ Biohub NY, focusing on cellular and molecular mechanisms underlying cellular changes in chronic infection, cancer, or aging.
• Collaborate in our collective efforts to bioengineer immune cells for the detection and prevention of diseased states within Biohub NY and across the ecosystem of Biohubs and CZI activities.
• Demonstrate outstanding productivity based on a compelling record of scientific publication, collaboration, and IP generation.
• Contribute to understanding critical immune cell mechanisms governing tissue residency and detection of aberrant cell states, aiming to detect and prevent diseased states.
• Develop a transformative research vision and provide technical guidance and mentorship to team members.
• Engage with colleagues throughout the Biohub and Biohubs ecosystem to uphold our values of scholarly excellence, innovation, open communication, and partnership.
• Communicate progress and results clearly to colleagues and leadership.
• Publish and disseminate impactful findings as preprints (medRxiv, bioRxiv) and/or software repositories (e.g., Git Hub) and embrace the Open Science policy of the Biohub network.
• Collaborate with the CZ Biohub team to patent and license technologies resulting from your research.

• PhD or MD with relevant research experience.
• An exceptional publication record demonstrating creativity and productivity.
• A minimum of 3 years post‑doctoral experience or clinical training.
• Demonstrated leadership, track record of innovation, and collaborative ability.
• Supervisory or mentoring experience is a plus, especially for senior candidates.
• A creative vision to carry out or continue an innovative and impactful research program.
• Outstanding interpersonal and communication skills.
• Demonstrated commitment to open science and alignment with the mission and values of CZ Biohub.

The New York City, NY base pay range for a new hire in this role is $ – $. New hires are typically hired into the lower portion of the range, enabling employee growth over time. Actual placement is based on job‑related skills and experience, as evaluated throughout the interview process.

This role is a hybrid position requiring you to be onsite for at least 60% of the working month (approximately 3 days a week). Specific in‑office days will be determined by the…