Postdoctoral Fellow - Immune Cell Dynamics - Optogenetics

Postdoctoral Fellow - Immune Cell Dynamics - Optogenetics

New York, NY (Onsite)

Biohub is the first large‑scale initiative bringing frontier AI models, massive compute, and frontier experimental capabilities under one roof. We’re building a general‑purpose system to accelerate scientific discovery, integrating frontier AI models, biological foundation models, and lab capabilities, with the ultimate goal of curing disease. Our technology powers scientists around the world, translating AI capabilities into tools that accelerate research everywhere.

Our immune cell reprogramming team integrates foundational research on immunology and disease biology with AI‑modeling to develop engineered cells that harness our own immune system to detect and treat early signs of age‑related diseases, like cancer, Alzheimer’s, and Parkinson’s. These technologies will enable precise, context‑dependent therapeutic responses only when and where it is needed.

Our work brings together three powerhouse universities – Columbia University, The Rockefeller University and Yale University – into a single collaborative technology and discovery engine.

• Pursue large scientific challenges that cannot be pursued in conventional environments
• Enable individual investigators to pursue their riskiest and most innovative ideas
• Facilitate research by scientists and clinicians at our home institutions and beyond

We are a team of passionate individuals powered by technology, guided by scientific research, and driven by collaboration, working toward a mission to cure or prevent all disease.

The Parsa Lab, also known as the Immune Cell Dynamics and Function group, is currently accepting applications for a Postdoctoral fellow position. The Parsa group focuses on investigating the cellular and functional dynamics of T cells, exploring how T cell fate decisions are made and how these decisions impact their functions in different disease contexts. Using a combination of genetically engineered mice, disease models, and single‑cell technologies, we aim to uncover the principles governing T cell fate and their functional roles across tissues.

This position is to develop novel methods and tools to determine the migratory dynamics of immune cells, with focus on T cells, and how that affects their cellular profile, function and longevity. It is an outstanding opportunity to collaborate with a team of talented scientists working to address fundamental immunological questions, with potential applications in treating inflammatory disorders, autoimmunity, and cancer.

• Conduct independent and collaborative research in immunology and related areas
• Design and perform in vitro and in vivo immune cell assessment
• Establish tools and perform assays to assess immune cell migration
• Design, execute and analyze experiments
• Present experimental data (in both written and oral formats)
• Prepare manuscripts for publication in peer‑reviewed journals
• Follow advances in the field through published literature and conferences
• Work closely with fellow team members and other members at Biohub institutions
• Mentor research assistants and interns in the lab

• PhD degree in immunology, molecular biology, genetics, biochemistry, or a related field
• Proficiency in molecular cloning, CRISPR gene editing, and generation of constructs for viral transduction methods
• A strong sense of curiosity and drive to explore
• Demonstrated ability to conduct independent research and work in a team
• Excellent communication skills (both verbal and written)
• Ability to collaborate in a diverse environment

Strong applicants have skills in one or more of the following areas:

• Experience working with mice, particularly generating transgenic or genetically modified primary T cells (and mice).
• Experience with flow cytometry and microscopy (particularly bioluminescence and fluorescence microscopy), and other imaging modalities to detect and quantify reporter gene expression
• Strong knowledge of the existing literature in immunology, dogmas and challenges

The New York City, NY base pay range for a new hire in this role is $93,000.00.

We’re thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible.

• Provides a generous employer match on employee 401(k) contributions to support planning for the future.
• Paid time off to volunteer at an organization of your choice.
• Relocation support for employees who need assistance moving.

As set forth in the organization’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.