Computational Biologist II - Berger Laboratory

Opportunity at Memorial Sloan Kettering Cancer Center (MSK)

We are seeking a Computational Biologist to join the Berger Laboratory, affiliated with the Center for Molecular Oncology  role focuses on characterizing genetic mutations in human tumors and identifying biomarkers of cancer progression and therapeutic response using large scale next‑generation DNA and RNA sequencing.

• Process, analyze, and interpret next‑generation sequencing (NGS) data to address key scientific questions in cancer genomics and extract insights related to tumor progression and response to therapy.
• Develop, pilot, and implement bioinformatics pipelines for analysis of RNA‑Seq data from our novel whole‑transcriptome clinical test, MSK‑TARGET.
• Analyze and integrate mutational and gene expression data across multiple patient samples and assays to characterize biomarkers of response to oncology treatments including theranostics.
• Collaborate closely with clinicians, researchers, and investigators to support multidisciplinary research projects.
• Develop, document, and maintain well‑annotated, reproducible code following best practices.
• Prepare scientific reports and summaries for internal use and external publication.
• Present research findings, analytical approaches, and project updates at lab meetings and, as appropriate, at external conferences.

• Bachelor's or Master’s degree in Bioinformatics, Computational Biology, or a related discipline.
• Demonstrated experience analyzing next‑generation sequencing (NGS) data.
• Proficiency in one or more programming languages such as Python or R.
• Working knowledge of genomics pipelines and best practices for NGS data analysis.
• Experience using version control systems (e.g., Git Hub).
• Excellent written and verbal communication skills.

• Strong analytical and problem‑solving abilities.
• Ability to work independently while contributing effectively within collaborative teams.
• Attention to detail and commitment to reproducible, high‑quality scientific work.
• Ability to clearly communicate complex analytical results to diverse audiences.

• Experience in cancer genomics research.
• Familiarity with DNA and RNA sequencing analysis.
• Understanding of workflow management systems such as Nextflow.

• Schedule:
  
  Hybrid, Monday – Friday, 37.5 hours.
• Location:
  
  323
  
  E. 61st Street, NY, NY (Macklowe).
• Reporting to:
  Principal Investigator, Berger Laboratory (CMO).
• Pay Range: $ – $.

MSK is an equal‑opportunity and affirmative action employer committed to diversity and inclusion in all aspects of recruiting and employment. All qualified individuals are encouraged to apply and will receive consideration without regard to race, color, gender, gender identity or expression, sexual orientation, national origin, age, religion, creed, disability, veteran status or any other factor which cannot lawfully be used as a basis for an employment decision.

Federal law requires employers to provide reasonable accommodation to qualified individuals with disabilities. Please tell us if you require a reasonable accommodation to apply for a job or to perform your job. Examples of reasonable accommodation include making a change to the application process or work procedures, providing documents in an alternate format, using a sign language interpreter, or using specialized equipment.