Research Technician II

The Landau Lab at the New York Genome Center/Weill Cornell Medicine is seeking a highly motivated and detail-oriented experimental scientist to join our interdisciplinary team studying somatic evolution, cancer genomics, and epigenomics. The laboratory develops and applies cutting-edge single-cell, multi-omics, and cell-free DNA technologies to investigate how somatic mutations shape cellular behavior, clonal evolution, and human disease.

• Perform molecular biology workflows associated with DNA and RNA sequencing, including nucleic acid extraction, sample quality control, amplification, library preparation, purification, quantification, and sequencing submission;
• Process cultured cells, primary specimens, tissues, and cell or nuclei suspensions for genomic and functional assays;
• Perform single-cell and multi-omic workflows, including single-cell RNA sequencing, single-cell ATAC sequencing, combined DNA and RNA profiling, targeted genotyping, and single-cell whole-genome sequencing;
• Contribute to the development, optimization, miniaturization, and scaling of novel experimental methods for single-cell genomics, epigenomics, and cell-free DNA analysis;
• Assist with the implementation of high-throughput and automated laboratory workflows, including liquid-handling and plate-based processes;
• Collaborate with experimental and computational researchers to plan studies, coordinate sample processing, and ensure that generated data address the relevant biological questions;
• Maintain detailed, accurate, and timely records in electronic laboratory notebooks, sample-tracking systems, and project databases;
• Communicate experimental progress, results, and technical issues clearly during project meetings;
• Maintain laboratory organization, reagent inventories, equipment, and appropriate safety practices;
• Support multiple concurrent research and technology-development projects; and
• Perform other responsibilities as assigned.

Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions of the position.

• Bachelor s degree in molecular biology, biotechnology, biochemistry, genetics, genomics, biomedical engineering, or a related discipline;
• Prior hands-on experience in an academic, biotechnology, or clinical molecular biology laboratory;
• Experience with fundamental molecular biology techniques, including DNA and RNA handling, PCR, nucleic acid purification, quantification, and gel or fragment analysis;
• Strong organizational and documentation skills, including the ability to manage multiple samples and experiments simultaneously;
• Ability to follow established protocols while also identifying opportunities for troubleshooting and improvement;
• Strong written and verbal communication skills;
• Demonstrated reliability, initiative, curiosity, and eagerness to learn new technologies.

• One or more years of experience with next-generation sequencing library preparation;
• Experience with single-cell genomics, spatial genomics, or other high-throughput molecular assays;
• Experience processing tissues, primary cells, cell suspensions, or isolated nuclei;
• Experience with cell culture, flow cytometry, fluorescence-activated cell sorting, microscopy, or tissue dissociation;
• Familiarity with whole-genome sequencing, RNA sequencing, chromatin accessibility assays, targeted sequencing, or cell-free DNA workflows;
• Experience with assay optimization, protocol development, or systematic troubleshooting;
• Experience using liquid-handling automation, acoustic dispensing, or other high-throughput laboratory instrumentation;
• Basic familiarity with sequencing quality-control metrics or analysis environments such as R, Python, or the command line;
• Master s degree in a relevant discipline.

Candidates are not expected to have experience with every technology listed above. The laboratory will provide training in specialized methods based on the candidate s background and project responsibilities.

Technical and Professional

Skills:

Consistently demonstrates the skills and knowledge relevant to the role; strives to expand the depth and breadth of technical expertise; performs experiments carefully and reproducibly; works with integrity; prioritizes effectively; and delivers on commitments.

Collaborative and Communicative:
Works effectively with colleagues across experimental, computational, and clinical disciplines; communicates clearly; listens carefully; contributes constructively to team discussions; and values diverse perspectives and areas of expertise.

Adaptable and Innovative:
Embraces new technologies and changing research priorities; approaches technical challenges systematically; identifies opportunities to improve efficiency and experimental quality; takes initiative; and engages in scientific work with curiosity and enthusiasm.

The pay range for this position is $46,118.80 - $58,895.20. The base salary offered will vary depending on…