Research Technician II, Landau Lab

101 Avenue of the Americas, 7th Floor
New York , NY 10013
United States

The Landau Lab at the New York Genome Center/Weill Cornell Medicine is seeking a highly motivated and detail-oriented experimental scientist to join our interdisciplinary team studying somatic evolution, cancer genomics, and epigenomics. The laboratory develops and applies cutting-edge single-cell, multi-omics, and cell-free DNA technologies to investigate how somatic mutations shape cellular behavior, clonal evolution, and human disease.

The successful candidate will contribute to both technology development and biological research projects. The role will involve performing, optimizing, and scaling experimental workflows for next-generation sequencing, single-cell genomics, and functional genomics. The candidate will work closely with experimental scientists, computational biologists, clinicians, and external collaborators to generate high-quality genomic datasets from cultured cells, model systems, and patient-derived samples.

This is a primarily wet-laboratory position, although opportunities will be available to participate in sequencing quality control, data interpretation, and the integration of experimental and computational results. The ideal candidate will have a strong foundation in molecular biology, excellent laboratory and organizational skills, and an interest in developing and implementing new genomic technologies.

The Landau Lab provides substantial scientific and technical training. This position is particularly well suited for an early-career scientist seeking to develop expertise in experimental genomics and single-cell technologies before pursuing graduate or professional training, although this is not a requirement.
The position will primarily be based at Weill Cornell Medicine, with regular interaction and collaboration with teams at the New York Genome Center.

Key Responsibilities

Perform molecular biology workflows associated with DNA and RNA sequencing, including nucleic acid extraction, sample quality control, amplification, library preparation, purification, quantification, and sequencing submission;
Process cultured cells, primary specimens, tissues, and cell or nuclei suspensions for genomic and functional assays;
Perform single-cell and multi-omic workflows, including single-cell RNA sequencing, single-cell ATAC sequencing, combined DNA and RNA profiling, targeted genotyping, and single-cell whole-genome sequencing;
Contribute to the development, optimization, miniaturization, and scaling of novel experimental methods for single-cell genomics, epigenomics, and cell-free DNA analysis;
Assist with the implementation of high-throughput and automated laboratory workflows, including liquid-handling and plate-based processes;
Collaborate with experimental and computational researchers to plan studies, coordinate sample processing, and ensure that generated data address the relevant biological questions;
Maintain detailed, accurate, and timely records in electronic laboratory notebooks, sample-tracking systems, and project databases;
Communicate experimental progress, results, and technical issues clearly during project meetings;
Maintain laboratory organization, reagent inventories, equipment, and appropriate safety practices;
Support multiple concurrent research and technology-development projects; and
Perform other responsibilities as assigned.
Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions of the position.

Required Qualifications
Bachelor’s degree in molecular biology, biotechnology, biochemistry, genetics, genomics, biomedical engineering, or a related discipline;
Prior hands-on experience in an academic, biotechnology, or clinical molecular biology laboratory;

Experience with fundamental molecular biology techniques, including DNA and RNA handling, PCR, nucleic acid purification, quantification, and gel or fragment analysis;
Strong organizational and documentation skills, including the ability to manage multiple samples and experiments simultaneously;
Ability to follow established protocols while also identifying opportunities for…