Research Scientist – Fungal natural product chemist

Primary Work Address: 418 E 71st St #21, New York, NY, 10021

The laboratory of Dr. Samara Reck-Peterson at Weill Cornell Medicine in New York, NY is looking for an accomplished

Research Scientist with expertise in fungal natural productsalong with experience in mass spectrometry-based metabolomics anddata processing for targeted and non-targeted approaches with expertise in natural product chemistry. The Reck-Peterson Labstudies the mechanisms of intracellular transport at molecular,cellular, and organismal scales. Our research addresses fundamentalquestions in cell biology with direct relevance to human health and disease.

We use a wide range of approaches: protein biochemistry and invitro reconstitution, single-molecule biophysics, proteomics andgenomics, metabolomics, fungal genetics, evolutionary analysis,mammalian cell culture, and state-of-the-art live-cell imaging.

Through collaborations, we use cryo-electron microscopy and cryo-electron tomography to pursue structural studies of the transport machinery. For more information about Dr. Samara Reck-Peterson and the lab, please visit: (Use the "Apply for this Job" box below)./

This role will contribute to the Reck-Peterson lab’s research program on fungal biology and secondary metabolite production. Thelab discovered that peroxisomes in filamentous fungi move by“hitchhiking” on early endosomes; through a genetic screen weidentified a putative protein linker between the two organelles andfound that organelle dynamics play a role in the production of secondary metabolites. Current efforts are aimed at understanding the cell biology of secondary metabolite production.

This is one of two high-ranking, non-Investigator roles within thelab. Ideal candidates will be confident and comfortable in aleadership role, have a strong desire to serve as a trustedresource for other members of the lab, and contribute to the lab’sculture of doing collaborative science.

• Competitive compensation and comprehensive benefits.
• A collaborative, diverse, and supportive research environment.
• Access to cutting-edge facilities and core resources, includingcollaborative access to cryo-electron microscopy and cryo-electrontomography.
• Flexible scheduling and mentorship tailored to your next career stage.

• Research (approximately 80% effort). Support the collaborative research environment and provide guidance on technical and operational aspects of research.
• Develop, design, and implement research projects, and coordinate specialized and novel research functions.
• Design and execute mass spectrometry-based metabolomicsexperiments using targeted and non-targeted approaches; isolate,analyze, and characterize natural products, including unknowncompounds.
• Identify methodological problems in research protocols and develop and implement modifications to optimize experimentalresults.
• Develop innovative techniques and data analysis pipelinesrequired to meet research goals, and use software applications to assemble, manipulate, format, and perform statistical analyses ofcomplex data and to mine large metabolomic datasets.
• Conduct literature reviews to determine the most suitableresearch methods, and routinely review research activities to determine where new information, methods, or collaborations couldpositively impact projects.
• Review available technology and assist in bringing appropriatenew technology into the laboratory; may prepare specifications for equipment and supplies needed to support research.
• Prepare reports for presentation at scientific meetings and manuscripts for publication; write and edit manuscripts, fellowshipapplications, and portions of grants.
• Lab operations and mentoring (approximately 20% effort). Mentor graduate students, postdoctoral fellows, Research Associates, and other staff, and train lab members on specializedresearch methods such as fungal biology and metabolomics.
• Configure, operate, and maintain specialized equipment, andtrain others in its use as necessary.
• Serve as a senior member of the lab, acting as a resource forboth students and staff on a variety of issues, along with other duties as assigned by the Principal Investigator.
• Hold sole responsibility for…