Senior Scientist​/Principal Scientist, Quantitative Pharmacology; Contractor

Legend Biotech is a global biotechnology company headquartered in Somerset, NJ, developing advanced cell therapies across diverse platforms.

Senior Scientist/Principal Scientist, Quantitative Pharmacology (Contractor) – part of the Research & Early Development team based in Somerset, NJ. The position seeks a highly motivated and experienced quantitative pharmacologist to lead modeling and simulation efforts in support of gene and cell therapy products, with a focus on QSP and popPK modeling.
Contract Duration: 12 months.

• Lead QSP and popPK modeling activities across preclinical and clinical development stages.
• Play a pivotal role in shaping clinical pharmacology strategies, supporting regulatory submissions, and driving innovation in model-informed drug development (MIDD).
• Develop and apply mechanistic models to understand disease pathways, drug mechanisms, and patient variability.
• Conduct simulations to support dose selection, trial design, and exposure-response analyses.
• Collaborate cross-functionally with R&D, clinical, regulatory, and biostatistics teams.
• Author and review clinical pharmacology sections of regulatory documents (e.g., INDs, NDAs).
• Contribute to scientific publications and conference presentations.

• R&D, preclinical development, clinical, CMC, and regulatory experience.
• MS/PhD/Pharm D in Pharmaceutical Sciences, Clinical Pharmacology, Applied Mathematics, Biomedical Engineering, or related quantitative discipline.
• 7+ years of experience with an MS degree (or 3+ years with a PhD/Pharm
  
  D) in quantitative pharmacology, pharmacometrics, or related fields in pharmaceutical or CRO settings.
• Strong execution ability.
• Strong independent scientific research ability, logical thinking, and coordination/problem‑solving skills.
• Clear written and oral communication skills.
• Good team spirit.
• Proven expertise in QSP and popPK modeling, with proficiency in NONMEM, R, MATLAB, Monolix, etc.
• Deep understanding of PK/PD principles, translational medicine, and the role of quantitative pharmacology and MIDD in clinical trials and drug development.
• Experience applying modeling and simulation approaches to enable rational and efficient preclinical and clinical drug development.
• Familiarity with regulatory requirements and guidelines for clinical pharmacology.
• Good project management skills and ability to collaborate with internal and external partners.
• Track record of scientific contributions through publications or presentations.
• Professional, honest, trustworthy character.
• Physically and mentally healthy.

Benefits are offered exclusively to permanent full‑time employees. Contractors are not eligible for benefits through Legend Biotech.

It is the policy of Legend Biotech to provide equal employment opportunities without regard to actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, related medical conditions and lactation), gender identity or gender expression (including transgender status), sexual orientation, marital status, military service and veteran status, disability, genetic information, or any other protected characteristic under applicable federal, state or local laws or ordinances.

Employment is at‑will and may be terminated at any time with or without cause or notice by the employee or the company.

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