Manager​/Senior Manager, IT Infrastructure and Operations

Role Overview & Key Functions:

Karyopharm is seeking a Manager/Senior Manager, IT Infrastructure & Operations to serve as a senior individual contributor owning the architecture, reliability, and evolution of the company's infrastructure environment, reporting to the VP, Information Technology. This is a hands-on role operating with a high degree of autonomy, partnering across IT, Security, and the business to design and run scalable, secure infrastructure across a mix of cloud and legacy systems in a regulated environment.

This individual will lead complex initiatives end-to-end, drive modernization, and improve operational maturity across cloud and on-prem environments. Operating within a lean IT team, the role requires strong ownership, hands-on execution, and the ability to mentor others and influence infrastructure strategy without direct people management.

Key Responsibilities

Technical Leadership & Execution

* Serve as the senior technical lead for infrastructure design, architecture, and operations.

* Own and execute complex infrastructure initiatives end-to-end (design → build → optimize).

* Act as an escalation point for critical incidents and complex system issues.

* Lead by example through hands-on engineering, troubleshooting, and implementation work.

* Mentor and guide engineers through technical challenges, design reviews, and best practices (without direct management responsibility).

* Collaborate with IT Business Partners to identify and align solutions that balance meeting business needs and technical complexity

Infrastructure Strategy & Modernization

* Drive cloud-first and hybrid infrastructure strategy, including migration from legacy systems.

* Design and implement scalable solutions across AWS/Azure, on-prem systems, and networking layers.

* Partner with IT leadership to shape long-term infrastructure roadmaps and technical standards.

* Evaluate emerging technologies and recommend adoption aligned with business needs.

Operational Excellence & Reliability

* Design and enhance monitoring, alerting, and observability frameworks.

* Improve system reliability through proactive engineering (capacity planning, performance tuning, resilience design).

* Lead root cause analysis (RCA) and implement long-term fixes to reduce incident recurrence.

* Optimize operational workflows, including ticket triage, escalation paths, and service ownership.

* Define and monitor KPIs, SLAs, and SLOs to ensure service health and performance.

Security, Compliance & Risk Management

* Partner closely with Cybersecurity to ensure infrastructure aligns with SOX, GxP, and enterprise security standards.

* Implement secure architecture patterns (identity, access, network segmentation, encryption).

* Support audit readiness through strong documentation, system configuration visibility, and asset management.

* Lead infrastructure contributions to disaster recovery (DR) and business continuity planning (BCP).

Cross-Functional Collaboration & Influence

* Work across teams (Applications, Data, Security, PMO) to deliver infrastructure solutions that support business initiatives.

* Act as a trusted advisor to leadership on infrastructure capabilities, risks, and trade-offs.

* Collaborate with vendors and partners to evaluate and implement solutions.

* Drive alignment and adoption of infrastructure standards without formal authority.

Candidate Profile & Requirements:

Required Qualifications

* Bachelor's degree in Computer Science, Information Technology, or equivalent experience.

* 8-10+ years of deep, hands-on IT infrastructure experience.

* Proven ability to operate independently and lead large technical initiatives without direct reports.

* Strong expertise in:

* Microsoft ecosystem (Windows Server, Active Directory, Azure AD, O365)

* Cloud platforms (AWS and/or Azure)

* Networking (firewalls, routing, VPNs, VLANs, subnets), specifically Fortinet

* Virtualization (VMware, Hyper-V)

* Experience with automation (scripting, Terraform/Cloud Formation, etc.)

* Strong troubleshooting and systems thinking skills across complex environments.

* Experience working in regulated environments (SOX, GxP) preferred.

* Excellent communication skills with ability…