Senior Scientist

Overview

Bruker is one of the world’s leading analytical instrumentation companies enabling scientists to make breakthrough discoveries and develop new applications that improve the quality of human life. Our high-performance products and high-value life science and diagnostic solutions are trusted by leading businesses, institutes, and scientists worldwide. Today, more than 11,000 employees at over 90 locations are working on this permanent challenge to make the world a better place.

Bruker Spatial Genomics (BSG, a Bruker subsidiary) is focused on opening a new frontier in spatial 3D genomics and multiomic analyses. We are committed to the development of a novel technology platform allowing progress in genome-wide visualization of spatially resolved 3D chromosome and chromatin architecture in individual cells and cell populations in situ. We bring together the premier spatial omics approach, jebFISHTM, with leading-edge imaging, data acquisition and analysis capability.

Our pioneering in situ technology enables examination of some of the most important questions in genomics and gene expression at the single cell and sub‑cellular level. We aim to find the best talent in the field to join and contribute to this extraordinary endeavor, becoming a critical member of this groundbreaking opportunity.

• Key contributor to optimization and development of advanced bioassays for determination of chromosome and chromatin architecture using spatial omics approaches.
• Collaborate with scientists and engineers across multiple disciplines such as molecular biology, wet lab, and imaging; design and conduct cutting‑edge experiments to map spatial gene activity and expression, develop new technologies for multiomic integration, and oversee technique invention, optimization, and transfer to in‑situ imaging of gene activity, localization, and expression in diverse tissue (FF and FFPE) and cell types.
• Support the optimization of probe chemistry and probe‑based sequencing for spatial multi‑omic profiling applications.
• Help develop and optimize sample preparation methods such as tissue/cell fixation and permeabilization for diverse tissues (FF and FFPE) and cell types.
• Independently plan and execute experiments, accurately record details, provide in‑depth analysis, and report results through documentation and presentations.
• Assist and lead the analysis of large and complex data sets, including developing routines for streamlined and automated data pipelines.
• Prepare assay reagents and other components.
• Work within multidisciplinary teams at all stages of product development.
• Assist with research projects to profile spatial genomics and collaborate with other team members on research studies.
• Support and lead elements of the development, verification, and validation of product‑related kits and reagents.
• Analyze specimens on imaging instrumentation, analyze research data, and assist with data interpretation.
• Interface directly with product development teams to transfer and optimize new technologies.
• Prepare research reports and share findings with the team; write protocols, develop procedures, and maintain accurate records.
• Clearly communicate and present results, and contribute data for making critical design decisions.

Educational/Experience requirements:

• PhD in biophysics, chemical/biomolecular engineering, molecular biology, biochemistry, cell biology, or a related field and 5+ years of hands‑on molecular biology experience in an industrial setting.
• Proficient in standard molecular biology techniques such as sample preparation, nucleic acid amplification and purification (RNA/DNA), qPCR, and DNA sequencing or similar molecular biology techniques. Experience with applying microscopy to answer biological problems.
• Knowledge of advanced fluorescence in situ hybridization (FISH) or other in situ fluorescence probed–based techniques. Understanding of basic absorption and emission spectroscopy.
• Highly motivated with excellent attention to detail. Good communication (oral and written) and collaboration skills.
• Experience in cell culture and tissue (FF and FFPE) preparation techniques.
• Experience in…