Senior Scientist

Bruker is one of the world’s leading analytical instrumentation companies enabling scientists to make breakthrough discoveries and develop new applications that improve the quality of human life. Our high-performance products and high-value life science and diagnostic solutions are trusted by leading businesses, institutes, and scientists worldwide. Today, more than 11,000 employees at over 90 locations are working on this permanent challenge to make the world a better place.

Bruker Spatial Genomics (BSG, a Bruker subsidiary) is focused on opening a new frontier in spatial 3D genomics and multi‑omic analyses. We are committed to developing a novel technology platform that advances genome‑wide visualization of spatially resolved 3D chromosome and chromatin architecture in individual cells and cell populations in situ. Our approach combines the premier spatial omics methodology, jebFISHTM, with leading‑edge imaging, data acquisition, and analysis capabilities.

Our pioneering in situ technology enables examination of some of the most important questions in genomics and gene expression at the single‑cell and sub‑cellular level. We seek the best talent in the field to join and contribute to this extraordinary endeavor, becoming a critical member of this groundbreaking opportunity.

Bruker Spatial Genomics is looking for a Staff Scientist for its R&D team. The position and ideal candidate is described as follows.

• The candidate will be a key contributor to the optimization and development of advanced bioassays for determining chromosome and chromatin architecture through spatial omics approaches.
• This is a unique multidisciplinary position that will work closely with scientists and engineers with molecular biology, general wet‑lab, or imaging experience. As part of our team, you will design and conduct cutting‑edge approaches and experiments to map spatial gene activity and expression and develop new technologies for multi‑omic integration. You will conceptualize and oversee technique invention, optimization, and transfer of the leading approach to in‑situ imaging of gene activity, localization, and expression in diverse tissues (FF and FFPE) and cell types.
• The ideal candidate should have demonstrated wet‑lab experience working independently in a biophysics, chemistry, biochemistry, or molecular biology laboratory, have exceptional attention to detail, be creative, and be able to critically analyze data and communicate results to the team. This position must be able to independently make decisions on work direction.
• They should be enthusiastic to work as part of a team in a fast‑paced startup environment, and must bring a can‑do attitude and sense of purpose to the job.

• Support and spearhead the method development and optimization of novel molecular biology assay schemes for spatial omics applications, including molecular barcoding, fluorophore marking, nucleic acid hybridization, amplification and sequencing techniques, and probe library preparation.
• Support the optimization of probe chemistry and probe‑based sequencing for spatial multi‑omic profiling applications.
• Help develop the optimization of sample preparation methods such as tissue/cell fixation and permeabilization in diverse tissues (FF and FFPE) and cell types.
• Independently plan and execute experiments, accurately record details, provide in‑depth analysis, and report results through documentation and presentations.
• Assist or lead in the analysis of large and complex data sets, including developing routines for streamlined and automated data pipelines.
• Prepare assay reagents and other components.
• Work within multidisciplinary teams at all stages of product development.
• Assist with research projects to profile spatial genomics. Collaborate with other team members on research studies.
• Support and lead elements of the development, verification and validation of product‑related kits and reagents.
• Analyze specimens on imaging instrumentation. Analyze research data and assist with data interpretation.
• Interface directly with product development teams to transfer and optimize new technologies.
• Prepare research reports and share findings with…