Senior Scientist

Staff Scientist

Bruker Spatial Genomics is looking for a Staff Scientist for their R&D team. The position and ideal candidate is described as follows:

• The candidate will be a key contributor to optimization and development of advanced bioassays for determination of chromosome and chromatin architecture through the use of spatial omics approaches. This is a unique multi-disciplinary position that will work closely with a variety of disciplines including scientists and engineers with molecular biology, general wet lab, or imaging experience. As part of our team, you will design and conduct cutting edge approaches and experiments to map spatial gene activity and expression and develop new technologies for multiomic integration.

You will conceptualize and oversee technique invention, optimization, and transfer of the leading approach to in situ imaging of gene activity, localization, and expression in diverse tissue (FF and FFPE) and cell types.

• The ideal candidate should have demonstrated wet lab experience working independently in a biophysics, chemistry, biochemistry, or molecular biology laboratory, have exceptional attention to detail, be creative, and be able to critically analyze data and communicate results to the team. This position must be able to independently make decisions on work direction. They should be enthusiastic to work as part of a team in a fast-paced startup environment, and must bring a can-do attitude and sense of purpose to the job.

• Support and spearhead the method development and optimization of novel molecular biology assay schemes for spatial omic applications including molecular barcoding, fluorophore marking, nucleic acid hybridization, amplification and sequencing techniques, and probe library preparation.

• Support the optimization of probe chemistry and probe-based sequencing with spatial multi-omic profiling applications.

• Help develop the optimization of sample preparation methods such as tissue/cell fixation and permeabilization in diverse tissue (FF and FFPE) and cell types.

• Independently plan and execute experiments, accurately record details, provide in-depth analysis, and report results through documentation and presentations.

• Assist/lead in the analysis of large and complex data sets, including developing routines for streamlined and automated data pipelines.

• Prepare assay reagents and other components.

• Work within multidisciplinary teams at all stages of product development.

• Assist with research projects to profile spatial genomics. Collaborate with other team members on research studies.

• Support and lead elements of the development, verification and validation of product related kits and reagents.

• Analyze specimens on imaging instrumentation. Analyze research data and assist with data interpretation.

• Interface directly with product development teams to transfer and optimize new technologies.

• Prepare research reports and share findings with the team. Write protocols, develop procedures, and maintain accurate records.

• Clearly communicate and present results; contribute data for making critical design decisions.

Educational/Experience requirements:

• PhD in biophysics, chemical/biomolecular engineering, molecular biology, biochemistry, cell biology, or a related field and 5+ years of hands-on molecular biology experience in an industrial setting.
• Proficient in standard molecular biology techniques such as sample preparation, nucleic acid amplification and purification (RNA/DNA), qPCR, and DNA sequencing or similar molecular biology techniques. Experience with applying microscopy to answer biological problems.
• Knowledge of advanced fluorescence in situ hybridization (FISH) or other in situ fluorescence probed-based techniques. Understanding of basic absorption and emission spectroscopy.
• Highly motivated with excellent attention to detail. Good communication (oral and written) and collaboration skills.
• Experience in cell culture and tissue (FF and FFPE) preparation techniques.
• Experience in troubleshooting and optimization of molecular biology assays including reagent formulation and workflow optimization.
• Experience with…