Director​/Senior Director, Cardiovascular Clinical Development; EDG

Position: Director/Senior Director, Cardiovascular Clinical Development (EDG-2026036)

Location: All US

Job : 271

# of Openings: 1

At Edgewise, we discover new medicines to improve the lives of patients facing serious muscle disease. Our expertise in muscle biology and precision small‑molecule design enables rapid progression of skeletal and cardiac muscle candidates into the clinic and into a robust pre‑clinical pipeline. We build a leading global muscle disease biopharmaceutical company to dramatically enhance the lives of people living with progressive muscle disorders.

The Director/Senior Director of Cardiovascular Clinical Development is a key leader in the clinical organization, responsible for advancing the development of the company’s cardiovascular clinical assets. This role serves as a strategic partner to the Executive Director of Clinical Development and the broader cardiovascular team, contributing to clinical development strategy, operational excellence, and consistent execution of best‑in‑class clinical programs across the portfolio.

• Contribute to hypertrophic cardiomyopathy (HCM) and heart failure with preserved ejection fraction (HFpEF) clinical development strategy, emphasizing operational excellence and innovation.
• Serve as medical expert on early and late cardiovascular development programs and help plan clinical trials, testing clinical hypotheses and early proof of concept of assets.
• Act as a sponsor medical monitor to ensure participant safety.
• Analyze and summarize clinical findings to support decisions regarding safety, efficacy, new drug applications, clinical study reports, and publications.
• Participate in internal and joint research project teams relevant to new compound development; aid in selecting Scientific Advisory Committees and manage/participate in advisory board discussions.
• Contribute to clinical sections of regulatory documents (INDs, briefing documents for scientific advice, BLA).
• Develop strategies for complex regulatory issues and ensure continued regulatory compliance of products.
• Collaborate with Business Development to refine strategy and evaluate partnership opportunities.
• Identify and engage scientifically and operationally strong investigators for the company’s investigational compounds.
• Maintain relationships with prominent clinical investigators in the relevant field.
• Represent the company in external forums, enhancing the company’s profile through communication skills.
• Read, understand, and comply with all workplace health and safety policies and company procedures.
• Perform other duties as assigned by supervisor.

• MD or MD/PhD, Board Certified or Eligible in Internal Medicine; subspecialty training in Cardiovascular Medicine preferred.
• Minimum 3+ years of industry experience in drug development within pharma/biotech settings.
• Demonstrated success in overseeing clinical studies and protocols.
• Proven record of scientific scholarship and achievement.
• Strong cross‑functional collaboration skills and ability to build trust with internal and external stakeholders, including regulators, KOLs, universities, VCs, biotech companies, clinical community, patient groups, and policymakers.
• Excellent verbal, written, and presentation communications.
• Will travel on company business approximately 20–25% of the time.
• Entrepreneurial mindset with creative approach to developing innovative ideas.
• Ability to set clear, challenging goals and navigate ambiguity with adaptive leadership.
• Integrity, forethought, transparency, and consistency in decision making.
• Strong emotional intelligence and ability to influence and inspire teams.
• Encourages shared success and celebrates team achievements.

Salary range: $275,000 – $325,000, title and salary commensurate with experience.

Benefits include comprehensive medical, dental, vision, life and disability coverage; discretionary bonus, stock option grants, employee stock purchase plan, 401(k) with company match, and paid time off.

Edgewise does not accept resumes from recruitment agencies for this position. Please do not send resumes to Edgewise employees or the company location. Edgewise is not responsible for any fees related to unsolicited resumes.