Principal Research Scientist Eng

Abb Vie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas including immunology, oncology, neuroscience, and our Allergan Aesthetics portfolio.

R&D Process Engineering, part of Abb Vie’s Development Sciences organization in Synthetic Molecules CMC (Chemistry, Manufacturing, and Controls), designs and develops scalable processes to produce drug substances and drug products, including small molecules and antibody drug conjugates, throughout the pre‑clinical and clinical development stages. Responsibilities include synthetic route design, process definition, scale‑up, and tech transfer for a wide variety of therapeutics and technologies to meet evolving pipeline demand.

The R&D Process Engineering team partners with Biologics CMC Development and Aesthetics R&D functions to provide active engineering support for robust process scale‑up and manufacturing of biologics drug substances, drug products, toxins, lipid nanoparticles, and cosmetic active ingredients. We contribute to innovative engineering technologies, create valuable intellectual property, and support the development of the supply chain for pipeline molecules, helping to prepare and defend CMC regulatory content.

Chemical Engineers within Process Engineering support pipeline projects through all phases of development. In early development, engineers focus on establishing an enabling process that can be scaled up successfully. In the later stages, they optimize the drug substance and drug product processes, lead manufacturing campaigns, transfer optimized processes to manufacturing sites, develop control strategies, and prepare reports to support regulatory filings.

• Develop robust manufacturing processes, supporting assets through all phases of development.
• Participate in and/or lead project teams toward development and characterization of new small and large molecule assets, establishing, communicating, and executing research plans.
• Develop commercial‑ready manufacturing processes in the laboratory and demonstrate the processes in the pilot plant.
• Set project strategies, define project responsibilities and timelines, and provide leadership in a matrixed team setting.
• Address challenging problems with chemical and biochemical reactions, separations, and/or isolations using demonstrated expertise in reaction kinetics, transport phenomena, and mathematical modeling.
• Develop and apply process analytical technologies and data‑rich experimentation tools to build appropriate reaction and process understanding via model‑guided experimentation.
• Build data‑driven and knowledge‑driven models to facilitate successful scale‑up and tech transfer.
• Author and/or review technical documents summarizing process development efforts and contribute to regulatory filings.
• Exhibit a collaborative nature in identifying process challenges on a wide range of projects and communicate findings and recommendations effectively through multidisciplinary interactions with organic chemists, analytical chemists, process development engineers, pilot plant engineers, drug product development scientists, program managers, and regulatory affairs specialists.
• Author publications and present at scientific conferences.

• BS, MS, or PhD in Chemical/Bio Engineering or a related field and 14+ (BS), 12+ (MS), or 6+ (PhD) years of relevant industrial experience.
• Job level will be commensurate with academic and/or industrial work experience.
• Ph.D. candidates with pertinent research exposure are also encouraged to apply.
• Candidates are expected to have a strong background in chemical engineering and the proven ability to demonstrate their skills in this field.
• The candidate must demonstrate the ability to solve difficult technical problems and champion new technologies to achieve project goals.
• The candidate is required to be a strong team player and demonstrate scientific leadership, possessing effective oral and written communication skills for…