Principal Research Scientist, QTAS & ADME Sciences

Abb Vie’s mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas including immunology, oncology, neuroscience, and the Allergan Aesthetics portfolio.

Abb Vie is seeking a highly motivated and experienced scientist to join our Quantitative, Translation & ADME Sciences (QTAS) team in North Chicago. The ideal candidate will have a strong background in drug metabolizing enzyme function, drug‑drug interaction concepts, and quantitative bioanalysis, as well as the ability to drive cutting‑edge science and lead junior scientists. Experience in adjacent areas such as drug permeability and transport, receptor pharmacology, and pharmacokinetic modeling is desirable.

The role involves implementing innovative quantitative approaches to advance translational ADME using conventional and complex in vitro models, conducting in vitro assays, applying translational modeling concepts, and supporting global in vitro ADME strategy. The candidate will evaluate and implement new technologies to enhance mechanistic understanding of early and late‑stage small molecules, and may contribute to broader DMPK areas as warranted.

• Evaluating novel in vitro tools and methods, and applying established methods to improve prediction of human PK and drug‑drug interaction potential.
• Leading, mentoring, and coaching junior staff in established and novel practices in in‑vitro drug metabolism.
• Liaising with QTAS, discovery biology/pharmacology/chemistry scientists to generate data and knowledge supporting translational, mechanistic models.
• Communicating internally and externally on topics related to in‑vitro drug metabolism.
• Keeping up to date with emerging literature and science in modeling and in‑vitro approaches.
• Externalizing research through full‑length publications and oral presentations.

• BS or equivalent education with approximately 14+ years of experience; MS or equivalent education with approximately 12+ years of experience;
  PhD with approximately 6+ years of experience in the relevant discipline.
• Experience with in‑vitro ADME experiments and DMPK projects, either academic or industry.
• Deep understanding of drug metabolism and ADME principles, including enzyme kinetics, IVIVE, and DDI risk assessment.
• Strong publication record and strategic scientific leadership in the in‑vitro ADME field.
• Highly motivated, self‑driven, results‑oriented, excellent communication and presentation skills, capable of working independently and as a team player.
• Passion for generating ideas, learning, solving technical problems, and applying new technologies to advance scientific goals.

• Builds strong relationships with peers and cross‑functionally with partners outside the team.
• Inspires and leads others in areas of expertise.
• Learns quickly, grasps the essence, and can change course when indicated.
• Raises the bar and is never satisfied with the status quo.
• Creates a learning environment open to suggestions and experimentation for improvement.

• The compensation range described is the range of possible base pay the Company believes in good faith it will pay for this role at the time of posting, based on the job grade.
• We offer a comprehensive benefits package including paid time off, medical/dental/vision insurance, and a 401(k) for eligible employees.
• This job is eligible to participate in our long‑term incentive programs.

Abb Vie is an equal‑opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

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