Scientist I​/II, tLNP Formulation

Position: Scientist I / II, tLNP Formulation
Company Description

About Abb Vie

Abb Vie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about Abb Vie, please visit us at  Follow @abbvie on Linked In, Facebook, Instagram, X and You Tube.

Job Description

About the Team

The Targeted Lipid Nanoparticle (tLNP) drug product development group within Abb Vie's tLNP CMC team is committed to advancing clinical-stage tLNP assets from First-in-Human (FIH) through Phase 2. The team collaborates across biologics discovery, CMC partners, Clinical Operations, Regulatory Affairs, Quality Assurance, and external manufacturing to support development and commercialization of tLNP products. Key focus areas include establishing robust formulation and process development capabilities, leading critical CMC activities for pipeline programs, devising formulation development strategies, conducting stability evaluations, optimizing clinical in-use strategies, developing innovative product presentations, implementing stage-based quality risk management, and driving scientific initiatives to ensure the strong development of current and future tLNP programs.

Purpose

Abb Vie is seeking a highly motivated Scientist I/II to support the development of early-stage targeted Lipid Nanoparticle (tLNP) assets within Abb Vie's pipeline. The successful candidate will contribute to formulation and process development activities through hands-on laboratory experimentation, data analysis, and scientific problem solving. This role will work closely with cross-functional teams including analytical sciences, process development, manufacturing, and subject matter experts to advance tLNP drug product development from early research through clinical enablement.

Responsibilities

* Design, execute, and interpret formulation and process development experiments to support tLNP drug product development.

* Conduct formulation screening studies evaluating variables such as pH, buffer systems, cryoprotectants, surfactants, antioxidants, and other excipients to improve stability and performance of tLNP formulations.

* Support process development activities including formulation preparation, sterile filtration, freeze-thaw evaluations, lyophilization development, and other drug product unit operations.

* Generate high-quality experimental data and perform scientific analysis to support formulation and process optimization efforts.

* Apply statistical tools and Design of Experiments (DoE) approaches, with appropriate guidance, to evaluate formulation and process variables.

* Characterize tLNP formulations using relevant analytical and biophysical techniques and collaborate with analytical teams to interpret results.

* Support technology transfer, scale-up activities, and manufacturing readiness assessments by providing laboratory process knowledge and technical documentation.

* Evaluate formulation stability under various storage and stress conditions and contribute to development of clinical in-use strategies.

* Maintain detailed and accurate documentation of experimental procedures, results, and conclusions in electronic laboratory notebooks, technical reports, and presentations.

* Effectively communicate scientific findings and recommendations within project teams and cross-functional meetings.

* Continuously identify opportunities to improve laboratory methods, workflows, and scientific understanding.

* Maintain compliance with safety, quality, and good research practices while ensuring high laboratory productivity.

Qualifications

* Scientist I: BS in Pharmaceutics, Pharmaceutical Sciences, Chemical Engineering, Biotechnology, Chemistry, Biochemistry, Bioengineering, or a related scientific discipline with typically 5+ years of relevant industry experience, or MS with typically 2+ years of relevant industry experience.

* Scientist II: BS in Pharmaceutics, Pharmaceutical Sciences, Chemical Engineering, Biotechnology, Chemistry, Biochemistry, Bioengineering, or a related scientific discipline with typically 7+ years of relevant industry experience, or MS with typically 5+ years of relevant industry experience.

* Fundamental understanding of drug product formulation principles, protein biochemistry, stability, and analytical characterization.

* Demonstrated ability to independently execute experiments, analyze data, troubleshoot technical challenges, and communicate scientific findings.

* Experience with formulation development, process development, or characterization of biologics, nanoparticles, or related drug delivery systems.

* Knowledge of laboratory experimental design, data analysis, and scientific documentation practices.

* Strong written and verbal communication skills and ability to work…